Skip to main content
SpringerLink
Log in

Demonstration of retinoic acid isomers in human urine under physiological conditions

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Untransformed retinoic acid has never been demonstrated in human excreta under normal physiological conditions. We have developed a two-step liquid chromatographic system for the demonstration of subnanogram amounts of this compound in human urine without administration of any precursor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ito, Y. L., Zile, M., Ahrens, H., and DeLuca, H. F., J. Lipid Res.15 (1974) 517.

    Article  CAS  PubMed  Google Scholar 

  2. McCormick, A. M., Napoli, J. L., Schnoes, H. K., and DeLuca, H. F., Archs Biochem. Biophys.192 (1979) 577.

    Article  CAS  Google Scholar 

  3. Frolik, C. A., Roberts, A. B., Tavela, T. E., Roller, P. P., Newton, D. L., and Sporn, M. B., Biochemistry18 (1979) 2092.

    Article  CAS  PubMed  Google Scholar 

  4. Frolik, C. A., Roller, P. P., Roller, A. B., and Sporn, M. B., J. biol. Chem.255 (1980) 8057.

    Article  CAS  PubMed  Google Scholar 

  5. Hanni, R., and Bigler, F., Helv. chim. Acta60 (1977) 881.

    Article  CAS  PubMed  Google Scholar 

  6. Lippel, K., and Olson, J. A., J. Lipid Res.9 (1968) 168.

    Article  CAS  PubMed  Google Scholar 

  7. Zile, M. H., Schnoes, H. K., and DeLuca, H. F., Proc. natl. Acad. Sci. USA77 (1980) 3230.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Hanni, R., Bigler, F., Meister, W., and Englert, G., Helv. chim. Acta59 (1976) 2221.

    Article  CAS  PubMed  Google Scholar 

  9. Roberts, A. B., and DeLuca, H. F., Biochem. J.102 (1966) 600.

    Article  Google Scholar 

  10. Sundaresan, P. R., and Bhagavan, H. N., Biochem. J.122 (1970) 1.

    Article  Google Scholar 

  11. Swanson, B. N., Frolik, C. A., Zaharevitz, D. W., Roller, P. P., and Sporn, M. B., Biochem. Pharmac.30 (1980) 107.

    Article  Google Scholar 

  12. De Ruyter, M. G., Lambert, W. E., and De Leenheer, A. P., Analyt. Biochem.98 (1979) 402.

    Article  PubMed  Google Scholar 

  13. De Leenheer, A. P., Lambert, W. E., and Claeys, I., J. Lipid Res.23 (1982) 1362.

    Article  PubMed  Google Scholar 

  14. Jetten, A. M., and Jetten, M. E. R., Nature278 (1979) 180.

    Article  CAS  PubMed  Google Scholar 

  15. Shapiro, S. S., and Poon, J. P., Exp. Cell Res.119 (1979) 349.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoria voor Medische Biochemie en voor Klinische Analyse, Harelbekestraat 72, B-9000, Gent, Belgium

    W. E. Lambert & A. P. De Leenheer

Authors
  1. W. E. Lambert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. P. De Leenheer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The work was supported by a grant of the N.F.S.R. to W.L.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lambert, W.E., De Leenheer, A.P. Demonstration of retinoic acid isomers in human urine under physiological conditions. Experientia 41, 359–360 (1985). https://doi.org/10.1007/BF02004504

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02004504

Key words

Search

Navigation