Abstract
Three children with human immunodeficiency virus infection and invasive infection withMycobacterium genavense are reported. Fever spikes, abdominal cramps and distension, diarrhea or ileus, and anemia were the predominant symptoms in the severely immunodeficient patients (CD4 lymphocytes<0.04 × 109/l). Numerous acid-fast bacilli were readily detectable by microscopy in stool samples and in lymph node biopsies, but cultures for mycobacteria remained negative.Mycobacterium genavense should be sought when invasive non-tuberculous mycobacteriosis is suspected and mycobacterial cultures from blood or other sites show limited growth. Multiple-drug regimens including amikacin, ethambutol, rifampin, and clarithromycin may be of benefit in controlling the infection, as observed in two patients.
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References
Debrunner M, Salfinger M, Brändli O, von Graevenitz A Epidemiology and clinical significance of nontuberculous mycobacteria in HIV-negative patients in Switzerland. Clinical Infectious Diseases 1992, 15: 330–345.
Horsburgh CR Mycobacterium avium complex infection in the acquired immunodeficiency syndrome. New England Journal of Medicine 1991, 324: 1332–1338.
Husson RN Mycobacterial infections. In: Pizzo PA, Wilfert CM (ed): Pediatric AIDS. Williams & Wilkins, Baltimore, 1991, p. 209–224.
Ellner JJ, Goldberger MJ, Parenti DM Mycobacterium avium infection and AIDS: a therapeutic dilemma in rapid evolution. Journal of Infectious Diseases 1991, 163: 1326–1335.
Hirschel B, Chang HR, Mach N, Piguet PF, Cox J, Piguet JD, Silva MT, Larsson L, Klatser PR, Thole JER, Rigouts L, Portaels F Fatal infection with a novel, unidentified mycobacterium in a man with the acquired immunodeficiency syndrome. New England Journal of Medicine 1990, 323: 109–113.
Salfinger M, Kafader FM Comparison of two pretreatment methods for the detection of mycobacteria of Bactec and Loewenstein-Jensen slants. Journal of Microbiological Methods 1987, 6: 315–321.
Böddinghaus B, Rogall T, Flohr T, Blöcker H, Böttger EC Detection and identification of mycobacteria by amplification of rRNA. Journal of Clinical Microbiology 1990, 28: 1751–1759.
Böttger EC, Teske A, Kirschner P, Bost S, Chang HR, Beer V, Hirschel B Disseminated “Mycobacterium genavense” infection in patients with AIDS. Lancet 1992, 340: 76–80.
Boom R, Sol CJA, Salimans MMM, Jansen CL, Wertheim-van Dillen PME, van der Nordaa J Rapid and simple method for purification of nucleic acids. Journal of Clinical Microbiology 1990, 28: 495–503.
Rogall T, Flohr T, Böttger EC Differentiation ofMycobacterium species by direct sequencing of amplified DNA. Journal of General Microbiology 1990, 136: 1915–1920.
Edwards U, Rogall T, Blöcker H, Emde M, Böttger EC Isolation and direct nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acid Research 1989, 17: 7843–7853.
Horsburgh CR, Selik RM The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome. American Review of Respiratory Disease 1989, 139: 4–7.
Claydon EJ, Coker RJ, Harris JRW Mycobacterium malmoense infection in HIV positive patients. Journal of Infection 1991, 23: 191–194.
Young LS, Wiviott L, Wu M, Kolonoski P, Bolan R, Inderlied CB Azithromycin for treatment ofMycobacterium avium-intracellulare complex infection in patients with AIDS. Lancet 1991, 338: 1107–1109.
Hawkins CC, Gold JWM, Whimbey E, Kiehn TE, Brannon P, Cammarata R, Brown AE, Armstrong D Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Annals of Internal Medicine 1986, 105: 184–188.
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Nadal, D., Caduff, R., Kraft, R. et al. Invasive infection withMycobacterium genavense in three children with the acquired immunodeficiency syndrome. Eur. J. Clin. Microbiol. Infect. Dis. 12, 37–43 (1993). https://doi.org/10.1007/BF01997055
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DOI: https://doi.org/10.1007/BF01997055