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Use of sub-ambient DSC to complement conventional DSC and TG

The study of water adsorption of drug substances and excipients

  • Pharmaceuticals
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Abstract

Several drug substances or excipients are hygroscopic. The uptake or loss of water of such substances is generally difficult to control during processing or storage of drug products. DSC instruments with sub-ambient temperature equipment allow the determination of the amount of freezable water by measuring the corresponding melting enthalpy.

The determination of freezable water adds valuable information complementary to TG analysis for understanding the processing and storage of raw materials and drug products. Several substances were tested as is, without treatment, after storage at 92% r.h. and after equilibration with water. The results of these experiments showed that it was possible to demonstrate defined hydrate formation, to determine the upper level of binding of water in amorphous substances and to confirm reversible hydrate formations demonstrated by temperature resolved X-ray diffraction.

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References

  1. C. Ahlneck and G. Zografi, Int. J. Pharm., 62 (1990) 87.

    Article  CAS  Google Scholar 

  2. K. Umprayn and R. W. Mendes, Drug Dev. Ind. Pharm., 13 (1987) 653.

    Article  CAS  Google Scholar 

  3. S. R. Byrn, Solid State Chemistry of Drugs, Academic Press, 1982 p. 151.

  4. R. K. Kankari and D. J. W. Grant, Thermochim. Acta, 234 (1994) 153.

    Article  Google Scholar 

  5. M. Otsuka, N. Kaneniwa, K. Kawahami and O. Umezawa, J. Pharm. Pharmacol., 42 (1990) 606.

    CAS  Google Scholar 

  6. H. Ando, M. Ishii, M. Kayano and S. Wanatabe, Drug Dev. Ind. Pharm., 21 (1995) 2227.

    Article  CAS  Google Scholar 

  7. M. Otsuka, Drug Dev. Ind. Pharm., 19 (1993) 541.

    Article  CAS  Google Scholar 

  8. E. Laine, Acta Pharm. Fenn., 92 (1983) 243.

    CAS  Google Scholar 

  9. J. Elder, Thermochim. Acta, 234 (1994) 153.

    Article  CAS  Google Scholar 

  10. K. R. Morris, A. W. Newman, D. E. Burgay, S. A. Ranadive, A. K. Singh, M. Szyper, S. A. Varia, H. G. Brittain and A. M. Serajuddin, Int. J. Pharm., 180 (1994) 195.

    Article  Google Scholar 

  11. C. A. Oskasen and G. Zografi, Pharm. Res., 7 (1990) 654.

    Article  Google Scholar 

  12. H. Zhu and D. I. W. Grant, Int. J. Pharm., 139 (1996) 33.

    Article  CAS  Google Scholar 

  13. D. Giron and C. Goldronn, Analusis, 7 (1979) 109.

    CAS  Google Scholar 

  14. Sandoz Pharma, unpublished data.

  15. D. Giron, M. Draghi, C. Goldbronn, S. Pfeffer and P. Piechon, J. Thermal Anal., 49 (1997) 907.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Analytical R and D, Chemical Development, Sandoz Pharma, Basel, Switzerland

    D. Giron & C. Goldbronn

Authors
  1. D. Giron
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  2. C. Goldbronn
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Giron, D., Goldbronn, C. Use of sub-ambient DSC to complement conventional DSC and TG. Journal of Thermal Analysis 49, 907–912 (1997). https://doi.org/10.1007/BF01996776

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  • DOI: https://doi.org/10.1007/BF01996776

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