Abstract
The potential involvement of increased mucus secretion in the antiulcer activity of a cytoprotective agent, pentacaine, and of the H2-antagonist ranitidine was studied in stressed rats. Cold-restraint stress decreased the gastric mucus content and induced haemorrhagic erosions in the stomach. Pretreatment with pentacaine and ranitidine dose-dependently diminished the extent of stress-induced gastric damage. Pentacaine prevented the depletion of mucus after stress, while ranitidine failed to affect it. In nonstressed rats only pentacaine was able to enhance mucus secretion. The stimulating effect of pentacaine on gastric mucus secretion may account for some of its antiulcer properties.
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Nosálová, V., Juránek, I. & Babulová, A. Effect of pentacaine and ranitidine on gastric mucus changes induced by cold-restraint stress in rats. Agents and Actions 33, 164–166 (1991). https://doi.org/10.1007/BF01993156
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DOI: https://doi.org/10.1007/BF01993156