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Cyclic AMP generating systems in vertebrate retina: Effects of histamine and an established retinal modulator, dopamine

  • Histamine and the Nervous System
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Abstract

Histamine (HA), 1–1000 μM, significantly stimulated both basal and forskolin-activated cAMP generation in chicken and adult hen retina. The action of HA was reproduced by the selective H2-receptor agonists dimaprit and 4-methyl-histamine, but not by the selective H1-receptor agonist 2-thiazolylethylamine, and it was antagonized by the specific H2-receptor blockers cimetidine and tiotidine, but not by the H1-receptor blocker mepyramine. In parallel experiments, dopamine, an established retinal neuromodulator acting through the D1-type of receptor, also stimulated basal and forskolin-driven adenylate cyclase activity in homogenate of chicken retina. It is suggested that chicken retina contains HA H2-receptors which are positively coupled to the adenylate cyclase system.

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Authors and Affiliations

  1. Department of Biogenic Amines, Polish Academy of Sciences, P-225, 90-950, Lodz-1, Poland

    J. Z. Nowak & B. Sek

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  1. J. Z. Nowak
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  2. B. Sek
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Nowak, J.Z., Sek, B. Cyclic AMP generating systems in vertebrate retina: Effects of histamine and an established retinal modulator, dopamine. Agents and Actions 33, 138–142 (1991). https://doi.org/10.1007/BF01993149

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