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Comparison of histamine release in cord blood and adult blood

  • Histamine Release from Mast Cells and Basophils
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Abstract

Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults.

The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release.

Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood.

Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.

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Authors and Affiliations

  1. Department of Pediatrics, University Hospital of Aarhus, Nørrebrogade 44, 8000, Aarhus C, Denmark

    B. W. Nielsen, T. M. Engberg, T. Bjerke & P. O. Schiøtz

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  1. B. W. Nielsen
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  2. T. M. Engberg
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  3. T. Bjerke
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  4. P. O. Schiøtz
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Nielsen, B.W., Engberg, T.M., Bjerke, T. et al. Comparison of histamine release in cord blood and adult blood. Agents and Actions 33, 64–66 (1991). https://doi.org/10.1007/BF01993128

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  • DOI: https://doi.org/10.1007/BF01993128

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