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Effect of histamine on cyclic AMP levels in the submandibular gland

  • Histamine and the Gastrointestinal Tract
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Abstract

Histamine and 4-methylhistamine increased the cyclic AMP level in chopped guinea-pig submandibular glands. 4-Methylhistamine was more active than histamine. 2-(2-Pyridyl)ethylamine was less active than histamine or almost inactive. Metiamide markedly antagonized the histamine-induced cyclic AMP increase but mepyramine had no inhibitory effect on this increase.

These results suggest that there are H2-receptors which mediate the cyclic AMP response to histamine in the guinea-pig submandibular gland.

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Authors and Affiliations

  1. Department of Pharmacology, Okayama University Medical School, 700, Okayama, Japan

    K. Saeki, S. Seo, M. Murakami & I. Ikehara

Authors
  1. K. Saeki
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  2. S. Seo
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  3. M. Murakami
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  4. I. Ikehara
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Saeki, K., Seo, S., Murakami, M. et al. Effect of histamine on cyclic AMP levels in the submandibular gland. Agents and Actions 11, 156–157 (1981). https://doi.org/10.1007/BF01991487

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