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Histamine release from rat mast cells induced by protamine sulfate and polyethylene imine

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Abstract

The protamine sulfate-induced release of histamine from rat mast cells is a non-cytotoxic reaction, similar to the 48/80-induced secretion. Polyethylene imine was found to be a less potent releaser. It is a cytotoxic substance without specificity for mast cells and acts on membranes generally. Although the two agents are related concerning their molecular weight and polybasicity, their mode of action on mast cells is clearly different.

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References

  1. W.D.M. Paton,Histamine Release by Compounds of Simple Chemical Structure, Pharmac. Rev.9, 269 (1957).

    Google Scholar 

  2. D.E. Smith,Nature of the Secretory Activity of the Mast Cell, Am. J. Physiol.193, 573 (1958).

    PubMed  Google Scholar 

  3. S. Schnitzler, H. Renner, G. Steinhauser andK. Fechner,Fluorescence Microscopical Visualization of Rat Mast Cells by Means of Fluorescine Isothiocyanate Labeled Protamine Sulfate, Acta biol. med. germ.37, 509 (1978).

    PubMed  Google Scholar 

  4. B. Uvnäs andI.L. Thon,Isolation of ‘Biologically Intact’ Mast Cells, Exp. Cell Res.18, 512 (1959).

    PubMed  Google Scholar 

  5. T.J. Sullivan, K.L. Parker, W. Stenson andC.W. Parker,Modulation of Cyclic AMP in Purified Mast Cells. I. Responses to Pharmacologic, Metabolic and Physical Stimuli. J. Immunol.114, 1473 (1975).

    PubMed  Google Scholar 

  6. P.A. Shore, A. Burkhalter andV.H. Cohn Jr,A Method for the Fluorometric Assay of Histamine in Tissues, J. Pharmac. exp. Ther.127, 182 (1959).

    Google Scholar 

  7. H. Franz, B. Haustein, K. Geske, U. Kuropka andU. Pfüller,Die Wirkungsweise von Protaminsulfat auf die Erythrozytenagglutination durch Rh-Antiseren, Ursache der Zeitabhängigkeit, Z. Immun.-Forsch.151, 350 (1976).

    Google Scholar 

  8. O.S. Dermer andG.E. Ham,Ethylenimine and Other Aziridines — Chemistry and Applications (Academic Press, New York 1969).

    Google Scholar 

  9. P. Röhlich, P. Anderson andB. Uvnäs,Electron Microscopic Observations on Compound 48/80-Induced Degranulation in Rat Mast Cells. Evidence for Sequential Exocytosis of Storage Granules, J. Cell Biol.51, 465 (1971).

    PubMed  Google Scholar 

  10. P.-G. Krüger andG.D. Bloom,Granule Alteration and Vacuole Formation, Two Primary Features of the Histamine Release Process in Mast Cells, Experientia29, 329 (1973).

    PubMed  Google Scholar 

  11. R.H. Hino, C.K.H. Lau andG.W. Read,The Site of Action of the Histamine Releaser Compound 48/80 in Causing Mast Cell Degranulation, J. Pharmac. exp. Ther.200, 658 (1977).

    Google Scholar 

  12. S. Schnitzler, G. Steinhauser, H. Renner andG. Grochalski,Zur Wirkungsweise von Protaminsulfat bei der Histaminsekretion aus Rattenmastzellen, Acta biol. med. germ. (in press).

  13. W. Kazimierczak andB. Diamant,Mechanisms of Histamine Release in Anaphylactic and Anaphylactoid Reactions, Progr. Allergy24, 295 (1978).

    Google Scholar 

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Authors and Affiliations

  1. Institut für Wirkstofforschung, Akademie der Wissenschaften der DDR, 1136, Berlin, DDR

    S. Schnitzler & H. Renner

  2. Staatliches Institut für Immunpräparate und Nährmedien, 1120, Berlin, DDR

    U. Pfüller

Authors
  1. S. Schnitzler
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  2. H. Renner
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  3. U. Pfüller
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Schnitzler, S., Renner, H. & Pfüller, U. Histamine release from rat mast cells induced by protamine sulfate and polyethylene imine. Agents and Actions 11, 73–74 (1981). https://doi.org/10.1007/BF01991461

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  • DOI: https://doi.org/10.1007/BF01991461

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