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Pharmacology of interleukin-1-induced neutrophil migration

  • Future Trends in the Therapy of Inflammatory Disease
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Abstract

Neutrophil (PMN) accumulation induced by interleukin-1β (IL-1β, 5–20 ng) into the mouse air pouch was inhibited in a dose-dependent manner (2–200 μg) by concomitant injection of IL-1 receptor antagonist (IL-1RA). Similarly, co-administration of the neuropeptideα-melanocyte-stimulating hormone (α-MSH) resulted in a reduction of the number of migrated PMN but only at the highest dose tested (200 μg). Although IL-1RA does not select between the two types of receptor so far described for IL-1, the effectiveness ofα-MSH suggests that this property of the cytokine may occur through IL-1 type I receptor. This observation was confirmed by using a specific monoclonal antibody (mAb) raised against this receptor type, and which strongly inhibited (87%) IL-1-induced PMN recruitment.

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, The William Harvey Research Institute, The Medical College of Saint Bartholomew's Hospital, Charterhouse Square, EC1M 6BQ, London, England

    M. Perretti & R. J. Flower

  2. Department of Experimental Pathology, The William Harvey Research Institute, The Medical College of Saint Bartholomew's Hospital, Charterhouse Square, EC1M 6BQ, London, England

    I. Appleton

  3. Istituto Ricerche Immunobiologiche Siena, Via Fiorentina 1, 53100, Siena, Italy

    L. Parente

Authors
  1. M. Perretti
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  2. I. Appleton
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  3. L. Parente
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  4. R. J. Flower
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Perretti, M., Appleton, I., Parente, L. et al. Pharmacology of interleukin-1-induced neutrophil migration. Agents and Actions 38 (Suppl 2), C64–C65 (1993). https://doi.org/10.1007/BF01991139

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