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Chromosomal mapping of the human interleukin-1 receptor antagonist gene (IL-1RN) and isolation of specific YAC clones

  • Future Trends in the Therapy of Inflammatory Disease
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Abstract

Using a panel of somatic rodent-human cell hybrids, we show that the interleukin-1 receptor antagonist gene (IL-1RN) maps to the long arm of human chromosome 2. Linkage studies permitted the regional localization of this gene to band q14-21. This is the same region in which the IL-1α and IL-1β genes are localized. Three yeast artificial chromosome (YAC) clones containing the IL-1RN gene were isolated, and these will be used for further characterization of this chromosome 2 region.

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References

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Authors and Affiliations

  1. MRC Immunochemistry Unit, Dept. Biochemistry, South Parks Road, OX1 3QU, Oxford, UK

    A. Steinkasserer & R. B. Sim

  2. Clare Hall Laboratory, ICRF, South Mimms, EN6 3LD, Potters Bar, Herts, UK

    N. K. Spurr

Authors
  1. A. Steinkasserer
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  2. N. K. Spurr
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  3. R. B. Sim
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Steinkasserer, A., Spurr, N.K. & Sim, R.B. Chromosomal mapping of the human interleukin-1 receptor antagonist gene (IL-1RN) and isolation of specific YAC clones. Agents and Actions 38 (Suppl 2), C59–C60 (1993). https://doi.org/10.1007/BF01991137

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  • DOI: https://doi.org/10.1007/BF01991137

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