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The inhibitory action of ethanol on the gastric mucosa and its interaction with the vagus in rats

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Abstract

The influence of systemic ethanol and/or the vagus on ionic secretion and on glandular mucosal blood flow (GMBF) was studied in anex-vivo gastric chamber preparation in rats. Sub-diaphragmatic vagotomy decreased H+ secretion and Na+ outflux from the gastric mucosa. Subcutaneous injection of 50% ethanol significantly potentiated these responses, but not the concentrations of 25% and 100%. The three doses of ethanol did not affect the secretion of both H+ and Na+ in vagus-intact animals. Ethanol, however dose-dependently reduced the GMBF in both vagus-intact and sub-diaphragmatic vagotomised rats, and the effect was greater in the latter-operated animals. It is concluded that vagus nerves greatly influence the secretion of both H+ and Na+ the gastric mucosa but the effect is unrelated to GMBF. Systemic ethanol reduced the secretion of these ions only in vagotomised animals, indicating the vagus could play a role in modulating the action of ethanol in the stomach.

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References

  1. R. H. Chittenden, L. B. Mendel and H. C. Jackson,A further study of the influence of alcohol and alcoholic drinks upon digestion, with special reference to secretion. Am. J. Physiol.1, 164–209 (1898).

    Google Scholar 

  2. H. D. Becker, D. D. Reeder and J. C. Thompson,Gastrin release by ethanol in man and in dogs. Ann. Surg.179, 906–909 (1974).

    PubMed  Google Scholar 

  3. E. R. Woodward, D. S. Slotten and V. C. Tillmanns,Mechanism of alcoholic stimulation on gastric secretion. Proc. Soc. Exp. Biol. Med.89, 428–431 (1955).

    PubMed  Google Scholar 

  4. B. I. Hirschowitz, H. M. Pollard, S. W. Hartwell and J. London,The action of ethyl alcohol on gastric acid secretion. Gastroenterology30, 244–253 (1956).

    PubMed  Google Scholar 

  5. L. Varin, P. del Soldato, D. Foschi and M. D. Rosa,Further evidence on gastric cytoprotection exerted by pirenzepine. Pharmacol. Res. Commun.16, 653–665 (1984).

    PubMed  Google Scholar 

  6. S. H. Hong, C. H. Cho and C. W. Ogle,Protection by zinc sulphate against ethanol-induced ulceration: Preservation of the gastric mucosal barrier. Pharmacology33, 94–102 (1986).

    PubMed  Google Scholar 

  7. W. A. Mersereau and E. J. Hinchey,Effect of gastric acidity on gastric ulceration induced by hemorrhage in the rat, utilizing a gastric chamber technique. Gastroenterology64, 1130–1135 (1973).

    PubMed  Google Scholar 

  8. A. P. Shepherd and G. L. Riedel,Continuous measurement of intestinal mucosal blood flow by laser-doppler velocimetry. Am. J. Physiol.242, G668–G672 (1982).

    PubMed  Google Scholar 

  9. Y. K. Poon, C. H. Cho and C. W. Ogle,Sub-diaphragmatic vagotomy attenuates the protective action of paracetamol against ethanol-induced gastric damage in rats. Med. Sci. Res.16, 1285 (1988).

    Google Scholar 

  10. J. M. Henegan, G. S. Smith, E. R. Seidel and T. A. Miller,Influence of vagotomy on mucosal protection against alcoholinduced gastric damage in the rat. Gastroenterology97, 903–908 (1984).

    Google Scholar 

  11. C. H. Cho, C. W. Ogle, S. H. Wong and M. W. L. Koo,Effects of zinc sulphate on ethanol- and indomethacin-induced ulceration and changes in prostaglandin E 2 and histamine levels in the rat gastric glandular mucosa. Digestion32, 288–295 (1985).

    PubMed  Google Scholar 

  12. R. A. Harris and F. Schroeder,Ethanol and the physical properties of brain membranes. Fluorescence studies. Mol. Pharmacol.20, 128–137 (1981).

    PubMed  Google Scholar 

  13. R. C. Lyon, J. A. McComb, J. Schreurs and D. B. Goldstein,A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols. J. Pharmacol. Exp. Therap.218, 669–675 (1981).

    Google Scholar 

  14. J. Puurunen,Effect of prostaglandin E 2,cimetidine, and atropine and ethanol-induced gastric damage in the rat. Scand. J. Gastroent.15, 485–488 (1980).

    PubMed  Google Scholar 

  15. J. H. Chin and D. Goldstein,Drug tolerance in biomembranes: A spin label study of the effects of ethanol. Sci. Am.196, 684–685 (1977).

    Google Scholar 

  16. R. A. Gonzales and F. T. Crews,Correlation of ethanol's membrane actions and inhibition of receptor-stimulated histamine release from rat mast cells. J. Pharmacol. Exp. Therap.239, 111–116 (1986).

    Google Scholar 

  17. K. Y. K. Poon,The antagonistic effect of paracetamol on ethanol-induced gastric damage in rats. M. Phil. Thesis, University of Hong Kong (1989).

  18. S. H. Wong,The gastric effects of ethanol and their modulation by drugs in rats. Ph. D. Thesis, University of Hong Kong (1989).

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  1. Department of Pharmacology Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Hong Kong

    C. H. Cho

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Cho, C.H. The inhibitory action of ethanol on the gastric mucosa and its interaction with the vagus in rats. Agents and Actions 35, 135–139 (1992). https://doi.org/10.1007/BF01990963

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  • DOI: https://doi.org/10.1007/BF01990963

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