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Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors?

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  • Pharmacology, Tocicology
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Summary

The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitiors of cyclo-oxygenase and prostacyclinsynthetase.

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Authors and Affiliations

  1. Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina (CONICET), Serrano 665/69, 1414, Buenos Aires, Argentina

    E. Borda, L. Sterin-Borda, M. F. Gimeno, M. Lazzari & A. L. Gimeno

  2. Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina, Serrano 665/69, 1414, Buenos Aires, Argentina

    E. Borda, L. Sterin-Borda, M. F. Gimeno, M. Lazzari & A. L. Gimeno

Authors
  1. E. Borda
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  2. L. Sterin-Borda
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  3. M. F. Gimeno
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  4. M. Lazzari
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  5. A. L. Gimeno
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Additional information

This work has been supported by grant 6638 from CONICET (Argentina).

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Borda, E., Sterin-Borda, L., Gimeno, M.F. et al. Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors?. Experientia 39, 894–896 (1983). https://doi.org/10.1007/BF01990425

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  • DOI: https://doi.org/10.1007/BF01990425

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