Summary
The stimulating or inhibiting influences of 33 phenolic compounds on the prostaglandin synthetase of rat renal medulla were tested. Dihydroxyphenylcarbonic acids clearly proved to be activators of the prostaglandin synthetase. Dimethoxyphenylcarbonic acids were ineffective. Aminoethylphenols as well as p-substituted monohydroxybenzenes with a carbonic acid side chain were clear stimulators in contrast to their alkyl derivatives which are pronounced inhibitors. Among the tested bioflavonoids (+)-cyanidanol-3 and morin were inhibitors of the prostaglandin synthesis. Flavonoids with polar substitution in 3,5,7-position such as rutin on the other hand showed activating properties.
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Baumann, J., Bruchhausen, F.v. & Wurm, G. A structure-activity study on the influence of phenolic compounds and bioflavonoids on rat renal prostaglandin synthetase. Naunyn-Schmiedeberg's Arch. Pharmacol. 307, 73–78 (1979). https://doi.org/10.1007/BF00506554
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DOI: https://doi.org/10.1007/BF00506554