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Dantrolene: evidence for effects on Na permeability properties of the nodal membrane

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Summary

The effects of dantrolene on myelinated frog nerve fibers were studied in voltage clamp experiments. Dantrolene shifted the potential-dependent parameters describing Na+ permeability towards more negative membrane potentials. The findings are interpreted as a change in the negative surface charge of the membrane.

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Authors and Affiliations

  1. Physiologisches Institut, Universität Hamburg, Universitäts-Krankenhaus Eppendorf, Martinistrasse 52, D-2000, Hamburg 20, Federal Republic of Germany

    J. R. Schwarz & R. P. Spielmann

Authors
  1. J. R. Schwarz
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  2. R. P. Spielmann
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Additional information

Acknowledgments. We thank Proff. B. Bromm and R. Rüdel for valuable comments on the manuscript. This work was supported by the Deutsche Forschungsgemeinschaft (Br 310/15-3).

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Schwarz, J.R., Spielmann, R.P. Dantrolene: evidence for effects on Na permeability properties of the nodal membrane. Experientia 39, 755–756 (1983). https://doi.org/10.1007/BF01990310

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  • DOI: https://doi.org/10.1007/BF01990310

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