Skip to main content
Log in

The short-term effects of ingested chrysotile asbestos DNA synthesis in the pancreas and other organs of a primate

  • Published:
Experientia Aims and scope Submit manuscript

Summary

Single oral administration of chrysotile asbestos to monkeys resulted 9 days later in the stimulation of DNA synthesis in the pancreas as evidenced by increased incorporation of tritiated thymidine.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Proceedings of Conference on Biological Effects of Ingested Asbestos, Durham, North Carolina, November 18–20, 1973. Environ. Health Perspect. (1974), vol. 9.

  2. W. J. Nicholson, C. J. Maggiore andI. J. Selikoff, Science177, 171 (1972).

    Google Scholar 

  3. H. P. Blejer andR. Arlon, J. occup. Med.15, 92 (1973).

    Google Scholar 

  4. Federal Register33, 27076 (September 28, 1973).

  5. American Water Works Association Research Foundation, J. Am. Water Works Ass. (September, 1974), part 2.

  6. P. M. Cook, G. E. Glass andJ. H. Tucker, Science,185, 853 (1974).

    Google Scholar 

  7. H. J. Wekman andB. A. Plantholt, Bull. envir. Contam. Toxicol.11, 267 (1974).

    Google Scholar 

  8. P. C. Elmes andJ. Simpson, Br. J. ind. Med.28, 226 (1971).

    Google Scholar 

  9. I. J. Selikoff, E. C. Hammond andJ. Seidman, Meeting of the Working Group to Assess Biological Effects of Asbestos, Lyon, France (October, 1972).

  10. E. C. Hammond, I. J. Selikoff andJ. Churg, Ann. N.Y. Acad. Sci.132, 519 (1965).

    Google Scholar 

  11. I. J. Selikoff, J. Churg andE. C. Hammond, J. Am. med. Ass.188, 22 (1964).

    Google Scholar 

  12. P. M. Stell andT. McGill, Lancet1973, 416

  13. I. J. Selikoff, E. C. Hammond andJ. Churg, J. Am. med. Ass.204, 106 (1968).

    Google Scholar 

  14. G. E. Westlake, H. J. Spjut andM. N. Smith, Lab. Invest.14, 2029 (1965).

    Google Scholar 

  15. R. D. Pontefract andH. M. Cunningham, Nature, Lond.243, 352 (1973)

    Google Scholar 

  16. G. Volkheimer, Acta hepat. gastroenterol20, 361 (1973).

    Google Scholar 

  17. C. Evans, R. J. Evans, A. Holmes, R. F. Hounam, D. M. Jones, A. Morgan andM. Walsh, Envir. Res.6, 180 (1973).

    Google Scholar 

  18. J. S. Harrington andF. J. C. Roe, Ann. N.Y. Acad. Sci.132, 439 (1965).

    Google Scholar 

  19. J. R. Dixon, D. B. Lowe, D. E. Richards, L. J. Craley andH. E. Stokinger, Cancer Res.30, 1068 (1970).

    Google Scholar 

  20. M. F. Stanton, J. natn. Cancer. Inst.52, 633 (1974).

    Google Scholar 

  21. D. E. Amacher, A. Alarip andS. S. Epstein, Envir. Health Perspect.9, 319 (1974).

    Google Scholar 

  22. D. E. Amacher, A. Alarif andS. S. Epstein, Envir. Res.10, 208 (1975).

    Google Scholar 

  23. I. Webster, Envir. Health Perspect.9, 199 (1974).

    Google Scholar 

  24. S. H. Zaidi, Envir. Health Perspect.9, 239 (1974).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Environmental Health Programs, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106. This work was supported by grants from the Cleveland and Rockefeller Foundations.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Epstein, S.S., Varnes, M. The short-term effects of ingested chrysotile asbestos DNA synthesis in the pancreas and other organs of a primate. Experientia 32, 602–604 (1976). https://doi.org/10.1007/BF01990187

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01990187

Keywords

Navigation