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Is β-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?

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Summary

β-(4-chlorophenyl)-GABA (Baclofen, Lioresal antagonized the excitant actions of acetylcholine and substance P to comparable extents.L-glutamate-induced excitation was affected to a lesser extent These findings do not support the suggestion that β-(4-chlorophenyl)-GABA is a specific substance P antagonist.

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Authors and Affiliations

  1. Department of Physiology, College of Medicine, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada

    J. W. Phillis

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  1. J. W. Phillis
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Additional information

Acknowledgments. The author is indebted to Ciba-Geigy (Canada) Ltd. for a gift of α-COPG.Brenda Robson provided technical assistance. This work was supported by grants from the CanadianM. R. C. and the university of Saskatchewan.

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Phillis, J.W. Is β-(4-chlorophenyl)-GABA a specific antagonist of substance P on cerebral cortical neurons?. Experientia 32, 593–594 (1976). https://doi.org/10.1007/BF01990181

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  • DOI: https://doi.org/10.1007/BF01990181

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