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Transformation of progesterone byCaldariella acidophila, an extreme thermophilic bacterium

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Summary

Caldariella Acidophila, a thermophilic bacterium, converts porgesterone (1) to pregn-4-en-3,6,20-trione (2), 5a-pregnan-3, 6, 20-trione (3), pregn-4-en-20a-ol-3-one (4), pregn-4-6β-ol-3, 20-dione (5) and pregn-4-en-6a-ol-3, 20-dione (6). Different patterns of these metabolites were obtained by modifying the incubation conditions and using differently treated biocatalysis.

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References

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  5. Purchased from Steraloids, Wilton, NH, USA.

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Authors and Affiliations

  1. Istituto per la Chimica di Molecole di Interesse Biologico del C.N.R., Via Toiano 2, Arco Felice, Naples, Italy

    M. De Rosa, A. Gambacorta, G. Sodano & A. Trabucco

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  1. M. De Rosa
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  2. A. Gambacorta
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  3. G. Sodano
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  4. A. Trabucco
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De Rosa, M., Gambacorta, A., Sodano, G. et al. Transformation of progesterone byCaldariella acidophila, an extreme thermophilic bacterium. Experientia 37, 541–542 (1981). https://doi.org/10.1007/BF01990036

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  • DOI: https://doi.org/10.1007/BF01990036

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