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Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice

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Summary

Early suppression, followed by a period of enhancement and finally, suppression, was seen when the spleen cell response to T and B cell mitogens was monitored during growth of an adenovirus 12-induced tumour in CBA black mice. The macrophage content of the tumour changed with time and these fluctuations correlated with the ability of tumour tissue extracts to enhance the normal spleen cell response to mitogen.

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Authors and Affiliations

  1. Department of Pathology, Sheffield University Medical School, Beech Hill Road, S10 2RX, Sheffield, England

    Veronica Britten & J. C. E. Underwood

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  1. Veronica Britten
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  2. J. C. E. Underwood
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Additional information

Acknowledgments. Thanks are dur to the Yorkshire Cancer Research Campaign, and the Cancer Research Committee of Sheffield University for financial support, also to Professor C.W. Potter for advice.

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Britten, V., Underwood, J.C.E. Changes in immune reactivity during growth of an adenovirus 12-induced transplantable tumour in CBA mice. Experientia 37, 504–505 (1981). https://doi.org/10.1007/BF01986164

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