Abstract
Histamine is released into the systemic circulation during anaphylaxis, by drugs and surgical procedures. Studies in animal models have shown that released histamine is one of the major mediators of arrhythmia occurring during anaphylaxis or the adminstration of histamine-releasing drugs. The variations in plasma histamine levels in dogs with a subacute coronary thrombosis were investigated and the effects of dimaprit and cimetidine on the electrocardiographic consequence of this thrombosis and on histamine release were assessed.
During the first day after the myocardial infarction a ventricular arrhythmia developed and plasma histamine levels were found significantly increased, reterning to the basal values when the sinusal rhythm was restored.
Dimaprit was able to decrease the number of ventricular extrasystoles and to modulate plasma histamine levels. The action of dimaprit on ECG was not reversed by pretreatment with cimetidine, which on the contrary was able to antagonize the decrease in plasma histamine concentrations induced by dimaprit perfusion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. Giotti, A. Guidotti, P.F. Mannaioni andL. Zilletti,The influence of adrentotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro, J. Physiol., Lond.184, 924–941 (1966).
W. Lorenz, A. Doenicke, B. Schöning andE. Neugebauer, The role of histamine in adverse reactions to intravenous agents. InAdverse Reactions to Anaesthetic Drugs, pp. 169–238 (Ed.J.A. Thorthon). Elsevier North Holland Biomedical Press, New York 1981.
C. Meyer-Burdorff, G. Seidel andF.S. Schluter,Freisetzung von Histamin und Serotonin bei extrakorporaler Zirkulation, Anaesthesist22, 212–216 (1973).
J. Sengens, V. Randolf andH. Katus,Ventricular arrhythmias in cardiac anaphylaxis, Naunyn-Schmildebergs Ach. Pharmak.300, 115–121 (1977).
R. Levi andJ.A. Burke,Cardiac anaphylaxis: SRS-A potentiates and extends the effects of released histamine, Eur. J. Pharmac.62, 41–49 (1980).
J.S. Cameron, M.S. Gaide, C.B. Altman, R.J. Myerburg andA.L. Bassett,Cimetidine blocks the adverse electrophysiologic effects of histamine in vitro after myocardial infarction in guinea pigs, Circulation68, 221 abst. (1983).
W. Lorenz, A. Doenicke, R. Meyer, H.J. Reimann, J. Kusche, H. Barth, H. Geesing, M. Hutzel andB. Weissenbacher,An improved method for the determination of histamine release in man: its application in studies with propanidid and thiopentone, Eur. J. Pharmac.18, 180–190 (1972).
R. Levi andG. Allan, Histamine-mediated cardiac effects. InDrug-Induced Heart Disease, pp. 377–395 (Ed.M. Bristow). Elsevier North-Holland Biomedical Press, Amsterdam 1980.
R. Ginsburg, M.R. Bristow, N. Kantrowitz, D.S. Baim andD.C. Harrison,Histamine provocation of clinical coronary artery spasm: implications concerning pathogenesis of variant angina pectoris, Am. Heart J.102, 819–822 (1981).
E. Masini, P. Blandina andP.F. Mannaioni,Mast cell receptors controlling histamine release: influence on the mode of action of drugs used in the treatment of adverse drug reactions, Klin. Wschr.60, 1031–1038 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Masini, E., Phanchenault, J., Pezziardi, F. et al. Histamine release during an experimental coronary thrombosis in awake dog. Agents and Actions 16, 227–230 (1985). https://doi.org/10.1007/BF01983146
Issue Date:
DOI: https://doi.org/10.1007/BF01983146