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Indirect adrenergic effect of compound 48/80 in cat cerebral arteries

  • Histamine and Kinins
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Abstract

Compound 48/80 evoked an increase in the spontaneous tritium release from cat cerebral arteries prelabelled with3H-NA. This increase was abolished after cervical gangliectomy, external calcium removal or in the presence of colchicine. Cocaine brought about an enhancement in the release of radioactivity elicited by compound 48/80 while diphenhydramine did not affect it. These results suggest that compound 48/80 has an indirect adrenergic effect in cat cerebral arteries which is not mediated by the release of histamine from mast cells.

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Authors and Affiliations

  1. Departmento de Fisiología, Facultad de Medicina, Universidad Autónoma, Arzobispo Morcillo 1, 34, Madrid, Spain

    Emilio J. Marco & Gloria Balfagón

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  1. Emilio J. Marco
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  2. Gloria Balfagón
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Marco, E.J., Balfagón, G. Indirect adrenergic effect of compound 48/80 in cat cerebral arteries. Agents and Actions 16, 310–312 (1985). https://doi.org/10.1007/BF01982864

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  • DOI: https://doi.org/10.1007/BF01982864

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