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Autoradiographic evidence for binding of3H-flunitrazepam (Rohypnol®) to melanin granules in the cat eye

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Summary

This autoradiographic study revealed after an i.v. injection an accumulation of3H-flunitrazepam in melanin granules of the pigment epithelium and of the choroid cells. It seems that after a short period, a large proportion of the strongly bound drug is released.

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Authors and Affiliations

  1. Pharmaceutical Research Department, F. Hoffmann-La Roche & Co., Ltd, CH-4002, Basel, Switzerland

    H. Kuhn

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  1. H. Kuhn
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Additional information

Acknowledgments. I thank Dr E. Kovács and Mrs V. Beuck for help in treating the animals and Miss C. Böhler and Mr R. Krauer for excellent technical assistance.

This drug, with a radiochemical purity of 99.2%, was prepared by Drs R. Schwob and J. Würsch, F. Hoffmann-La Roche & Co., Ltd, Basel, Switzerland.

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Kuhn, H. Autoradiographic evidence for binding of3H-flunitrazepam (Rohypnol®) to melanin granules in the cat eye. Experientia 36, 863–865 (1980). https://doi.org/10.1007/BF01978617

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  • DOI: https://doi.org/10.1007/BF01978617

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