Summary
In the rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
F. Buffoni, Pharmac. Rev.18 1163 (1966).
R. W. Schayer, Br. J. Pharmac.11, 472 (1956).
M. Delfosse, J. Pharm. belg.32, 264 (1977).
P. R. Imrie, E. Marley and D. V. Thomas, Br. J. Pharmac.64, 109 (1978).
W. P. Burkard, K. F. Gey and A. Pletscher, Biochem. Pharmac.11, 177 (1962).
W. P. Burkard, K. F. Gey and A. Pletscher Biochem. Pharmac.3, 249 (1960).
P. A. Shore and W. H. Cohn, Biochem. Pharmac.5, 91 (1960).
J. W. Black and C. R. Ganellin, Experientia30, 111 (1974).
E. Marley, in: Drug Interactions, p. 171. Ed. D. G. Grahame-Smith. The MacMillan Press Ltd, London 1977.
C. G. Uragoda and S. R. Kottegoda, Tubercle58 83 (1977).
C. G. Uragoda and S. C. Lodha, Tubercle60, 59 (1979).
B. Blackwell and E. Marley, Br. J. Pharmac.26, 142 (1966).
P. C. Waldmeier, J. J. Feldtrauer and L. Maître, J. Neurochem.29, 785 (1977).
P. C. Waldmeier, J. J. Feldtrauer and L. Maître, Archs Pharmac.297, suppl. 2, R57 (1977).
L. B. Hough and E. F. Domino, J. Pharmac. exp. Ther.208, 422 (1979).
R. I. Knight and I. R. Smith, Br. J. Pharmac.64, 404P (1978).
Suzuki Osamu, Yoshimao Katastuma and Masakazu Oya, Life Sci.24, 2227 (1979).
M. Jalfre and B. Bucher, Neuropharmacology Dept., Delalande Research Centre, Personal communication.
M. Strolin Benedetti, J. P. Kan and P. E. Keane, in: Monoamine oxidase: Structure, function and altered functions, p. 335. Ed. T. P. Singer, R. W. Von Korff and D. L. Murphy. Academic Press, New York 1979.
P. E. Keane, F. Chanoine and M. Strolin Benedetti, in: Monoamine oxidase: Structure, function and altered functions, p. 341. Ed. T. P. Singer, R. W. Von Korff and D. L. Murphy. Academic Press, New York 1979.
P. A. Shore, A. Burkhalter and V. H. Cohn, J. Pharmac. exp. Ther.127, 182 (1959).
D. V. Thomas and E. Marley, J. Chromat.148, 477 (1978).
E. Stahl, in: Thin-layer Chromatography, 2nd ed, p. 889. Springer, Berlin, Heidelberg, New York 1969.
C. W. Dunnett, J. Am. statist. Ass.50, 1096 (1955).
R. G. D. Steel, Biometrics15, 560 (1959).
B. J. Winer, Statistical Principles in Experimental Design, 2nd ed. McGraw-Hill Book Company, 1971.
J. S. Dawborne, Org. Mass Spectromet.6, 211 (1972).
M. A. Reilly and R. W. Schayer, Br. J. Pharmac.38, 478 (1970).
R. E. Shaff and M. A. Beaven, Analyt. Biochem.94, 425 (1979).
B. Kilgallon and D. M. Shepherd, Archs int., Pharmacodyn.233, 305 (1978).
S. Yamamoto, D. Francis and M. W. Greavies, Clin. exp. Derm.2, 389 (1977).
H. M. Lee and R. G. Jones, J. Pharmac. exp. Ther.95, 71 (1949).
R. P. Imrie, E. Marley and D. V. Thomas, Br. J. Pharmac.66, 1 73P (1979).
Author information
Authors and Affiliations
Additional information
The authors wish to thank Dr J. Mercier (Université Pierre et Marie Curie, Paris) for help in running the mass spectra, Mr B. Laquais for the statistical analysis and Mrs M. Farny for the preparation of the manuscript.
Rights and permissions
About this article
Cite this article
Benedetti, M.S., Ancher, J.F. & Sontag, N. Monoamine oxidase inhibitors and histamine metabolism. Experientia 36, 818–820 (1980). https://doi.org/10.1007/BF01978589
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01978589