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Inhibition of isolated rat liver RNA polymerases I and II by aminoacridines

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Summary

9-Aminoacridine and 2 derivatives which contain hydroxyalkylic or aminoalkylic side chains in the 9-position totally inhibit the transcription of calf thymus DNA by rat liver RNA polymerases I and II. This inhibitory action does not always appear to be completely related to the ability of aminoacridines to intercalate into the DNA template.

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Author notes

  1. E. Calendi

    Present address: Istituto di Genetica, Università di Sassari, Viale Mancini 5, 07100, Sassari, Italy

Authors and Affiliations

  1. Instituto di Fisiologia Generale, Università di Genova, Corso Europa, I-16132, Genova, Italy

    A. Zoncheddu, R. Accomando, E. Calendi & M. Orunesu

Authors
  1. A. Zoncheddu
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  2. R. Accomando
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  3. E. Calendi
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  4. M. Orunesu
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Zoncheddu, A., Accomando, R., Calendi, E. et al. Inhibition of isolated rat liver RNA polymerases I and II by aminoacridines. Experientia 36, 1151–1152 (1980). https://doi.org/10.1007/BF01976093

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  • DOI: https://doi.org/10.1007/BF01976093

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