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Long term stability of lysine vasopressin and of specifically tritiated lysine vasopressin in weakly acidic aqueous solutions

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Summary

Lysine vasopressin tritiated at meta position of tyrosine (1.9 Ci/mmole) decomposes during a long storage period, mainly as a result of radiolysis. The loss of specific activity by isotopic exchange with water is slow. The nonlabelled peptide undergoes only very minute decomposition (polymerization). Specific radioactivity declines with a half life of 47.4 months.

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Authors and Affiliations

  1. Institut für Molekularbiologie und Biophysik, Eidg. Technische Hochschule, ETH-Hönggerberg, CH-8093, Zürich, Switzerland

    V. Pliška, M. Meyer-Grass, N. Bersinger, L. Carlsson, P. Melin & H. Vilhardt

  2. Research Department, FERRING AB, S-20060, Malmö 30, Sweden

    V. Pliška, M. Meyer-Grass, N. Bersinger, L. Carlsson, P. Melin & H. Vilhardt

Authors
  1. V. Pliška
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  2. M. Meyer-Grass
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  3. N. Bersinger
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  4. L. Carlsson
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  5. P. Melin
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  6. H. Vilhardt
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Additional information

Acknowledgments. This research was supported by Swiss National Science Foundation, grant No.3.040.76 (V.P.). Some of the measurements (years 1969–70) were carried out at Roche Institute of Molecular Biology, Nutley, N.J., USA.

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Pliška, V., Meyer-Grass, M., Bersinger, N. et al. Long term stability of lysine vasopressin and of specifically tritiated lysine vasopressin in weakly acidic aqueous solutions. Experientia 36, 1145–1146 (1980). https://doi.org/10.1007/BF01976090

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  • DOI: https://doi.org/10.1007/BF01976090

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