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Cytotoxic effects of hexavalent chromium in cultured murine macrophages

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Abstract

The in vitro effect of hexavalent chromium (CrVI) on mouse peritoneal macrophages was investigated. Our results demonstrate the existence of a threshold concentration of 2.5 ΜM of CrVI above which chromium affects the viability of macrophages in a concentration dependent manner. Morphological changes were seen with increasing concentrations of chromium. Evidence is presented that protein production (virus-induced interferon) in murine peritoneal macrophages was impaired by hexavalent chromium at low concentrations, while random migration and phagocytic activity were only affected at high concentrations of CrVI.

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Authors and Affiliations

  1. Institute of Medical Microbiology, University of Aarhus, DK-8000, Aarhus C, Denmark

    Margot Martiny Christensen & Svend Ellermann-Eriksen

  2. Dept of Neurobiology, Institute of Anatomy, University of Aarhus, DK-8000, Aarhus C, Denmark

    Margot Martiny Christensen & Erik Ernst

Authors
  1. Margot Martiny Christensen
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  2. Erik Ernst
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  3. Svend Ellermann-Eriksen
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Christensen, M.M., Ernst, E. & Ellermann-Eriksen, S. Cytotoxic effects of hexavalent chromium in cultured murine macrophages. Arch Toxicol 66, 347–353 (1992). https://doi.org/10.1007/BF01973630

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  • DOI: https://doi.org/10.1007/BF01973630

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