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Archives of Toxicology

, Volume 64, Issue 4, pp 285–290 | Cite as

Comparative uptake, vascular transport, and cellular internalization of aflatoxin-B1 and benzo(a)pyrene

  • D. L. Busbee
  • J. O. Norman
  • R. L. Ziprin
Original Articles

Abstract

Studies of the uptake of benzo(a)pyrene (BaP) and aflatoxin-B1 (AFB1) after gastric instillation showed that BaP was absorbed via the intestinal lymphatic drainage and transported to the vascular circulation sequestered within lipoproteins in thoracic duct lymph, while AFB1 was absorbed with water soluble compounds into the gastrointestinal venous drainage and was not transported in association with lipoproteins. BaP was taken up into plasma lipoproteins over a broad concentration range, while AFB1 was not sequestered within lipoproteins over the same concentration range. Low density lipoproteins (LDL) facilitated BaP uptake into fibroblasts and impeded BaP uptake into hepatocytes. High density lipoproteins (HDL) facilitated BaP uptake into hepatocytes and impeded BaP uptake into fibroblasts. The uptake of AFB1 into either fibroblasts or hepatocytes was not affected by lipoproteins.

Key words

Aflatoxin-B1 Benzo(a)pyrene Vascular transport Lipoproteins Cellular internalization 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • D. L. Busbee
    • 1
    • 2
  • J. O. Norman
    • 1
  • R. L. Ziprin
    • 3
  1. 1.Division of Cell Biology, Department of Anatomy, College of Veterinary MedicineTexas A&M UniversityCollege StationUSA
  2. 2.Division of Toxicology, Department of Physiology and Pharmacology, College of Veterinary MedicineTexas A&M UniversityCollege StationUSA
  3. 3.Veterinary Toxicology and Entomology Research LaboratoryARS, USDACollege StationUSA

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