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Components of the renin-angiotensin system in the plasma ofBothrops jararaca

  • Histamine and Kinins
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Abstract

By means of high voltage electrophoresis experiments it could be demonstrated that the dipeptide hydrolase present in the plasma ofBothrops jararaca is similar to the angiotensin I converting enzyme of human plasma. Therefore, angiotensin I can be considered as a probable natural substrate for this potent snake peptidase in contrast to bradykinin, which is excluded in that case, since this snake plasma was previously found to be deficient in intrinsic kinin releasing system. On the other hand, the presence of angiotensinase activity in this snake plasma could also be demonstrated. Through the pharmacological comparison of angiotensin II with the pressor peptide released from theBothrops jararaca plasma by chymotrypsin, an indirect indication of the presence of angiotensinogen in the plasma of this reptile was obtained.

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References

  1. M. Rocha e Silva,Angiotensin and Bradykinin: a Study in Contrasts, Can. Med. Ass. J.90, 307 (1964).

    Google Scholar 

  2. P.Y. Wong, R.C. Talamo, G.H. Williams andR.W. Colman,Response of the Kallikrein-Kinin and Renin-Angiotensin Systems to Saline Infusion and Upright Posture, J. clin. Invest.55, 691 (1975).

    Google Scholar 

  3. A.A.C. Lavras, M. Fichman, E. Hiraichi, M.A. Boucault, T. Tobo, P. Schmuziger andL. Nahas,Deficiency of Kallikrein-Kinin System and Presence of Potent Kininase Activity in the Plasma of Bothrops jararaca (Serpentes, Crotalinae) (unpublished work).

  4. O.B. Henriques, Z.P. Picarelli andM.C.F. de Oliveira,Partial Purification of the Plasma Substrate for the Bradykinin-Releasing Enzyme from the Venom of Bothrops jararaca, Biochem. Pharmac.11, 707 (1962).

    Google Scholar 

  5. Z.P. Picarelli, O.B. Henriques andM.C.F. de Oliveira,Potentiation of Bradykinin Action on Smooth Muscle by Cysteine, Experientia18, 77 (1962).

    Google Scholar 

  6. V. Erspamer andG.F. Erspamer,Pharmacological Actions of Eledoisin on Extravascular Smooth Muscle, Br. J. Pharmac.19, 337 (1962).

    Google Scholar 

  7. R.F. Furchgott andS. Bhadrakom,Reactions of Strips of Rabbit Aorta to Epinephrine, Isopropylarterenol, Sodium Nitrite and Other Drugs, J. Pharmac. exp. Ther.108, 129 (1953).

    Google Scholar 

  8. N.E. Condon,A Modification of the Conventional Mercury Manometer for Blood-Pressure Recordings, Br. J. Pharmac.6, 19 (1951).

    Google Scholar 

  9. Y.S. Bakhle,Converting Enzyme in vitro. Measurement and Properties, InAngiotensin (Eds. I.H. Page and F.M. Bumpus; Springer-Verlag, Berlin, Heidelberg, New York, 1974), pp. 41–80.

    Google Scholar 

  10. L.T. Skeggs, J.R. Kahn, K. Lentz andN.P. Shumway,The Preparation, Purification and Amino Acid Sequence of a Polypeptide Renin Substrate, J. exp. Med.106, 439 (1957).

    Google Scholar 

  11. H.L. Nolly, R. Cabrera andJ.C. Fasciolo,Angiotensina II liberada por alfa. — quimotripsina, Revta Soc. argent. Biol.47, 259 (1971).

    Google Scholar 

  12. A.A.C. Lavras, M. Fichman, E. Hiraichi, T. Tobo, M.A. Boucault andP. Schmuziger,Observations on the Chymotrypsin Peptide Releasing Activity on Plasmas, Adv. exp. Med. Biol.21, 91 (1972).

    Google Scholar 

  13. J.W. Bean,Specificity in the Renin-Hypertensinogen Reaction, Am. J. Physiol.136, 731 (1942).

    Google Scholar 

  14. A.A.C. Lavras, M. Fichman, E. Hiraichi, M.A. Boucault andT. Tobo,Purificação inicial do peptide pressor liberado do plasma de Bothrops jararaca por quimotripsina, Ciênc. Cult., S. Paulo. Supl. 28o Reunião Anual, 580 (1976).

  15. R.K. Türker, S. Kaymakçalan andI.H. Ayhan,Effect of Prostaglandin E1 (PGE 1)on the Vascular Responsiveness to Norepinephrine and Angiotensin in the Anesthetized Rat, Arzneimittel-Forsch18, 1310 (1968).

    Google Scholar 

  16. A. Grollman andV.S.R. Krishnamurty,A New Pressor Agent of Renal Origin: its Differentiation from Renin and Angiotensin, Am. J. Physiol.221, 1499 (1971).

    Google Scholar 

  17. J.L. Prado andE.A. Carlini,Influence of Tetraethylammonium, Pentolinium and Hexamethonium on the Action of Hypertensin, Archs. int. Pharmacodyn.122, 100 (1959).

    Google Scholar 

  18. P.A. Khairallah, I.H. Page andR.K. Türker,Some Properties of Prostaglandin E 1 Action on Muscle, Archs. int. Pharmacodyn.169, 328 (1967).

    Google Scholar 

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Authors and Affiliations

  1. Serviço de Farmacologia do Instituto Butantan, São Paulo, Brasil

    A. C. Lavras (Fellows of the ‘Conselho Nacional de Pesquisas’ (National Research Council), Mina Fichman, Elisa Hiraichi, Marisa A. Boucault & Tomoyo Tobo

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  1. A. C. Lavras
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  2. Mina Fichman
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  3. Elisa Hiraichi
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  4. Marisa A. Boucault
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  5. Tomoyo Tobo
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Additional information

This research was sponsored in part by the ‘Fundo Especial de Despesas’ (Special Research Fund) of Instituto Butantan and FAPESP.

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Lavras, A.C., Fichman, M., Hiraichi, E. et al. Components of the renin-angiotensin system in the plasma ofBothrops jararaca . Agents and Actions 8, 141–145 (1978). https://doi.org/10.1007/BF01972417

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