Summary
Physical exercise increased the activities of arylsulphatase, cathepsin D and β-glucuronidase in mouse skeletal muscle but not in cardiac muscle. Exercise-induced lysosomal response was more prominent in young adult than in senescent mice. The lipofuscin content of cardiac and skeletal muscles increased markedly during ageing and was also found to increase slightly after exertion in young mice, but not in senescent ones.
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References
H.-J. Schumann, Zentbl. allg. Path. path. Anat.116, 181 (1972).
H.J. Hecht, H.-J. Schumann and D. Kunde, Med. Sport, Berl.15, 270 (1975).
A. Salminen and V. Vihko, unpublished observations.
V. Vihko, J. Rantamäki and A. Salminen, Histochemistry57, 237 (1978).
V. Vihko, A. Salminen and J. Rantamäki, Pflügers Arch.378, 99 (1978).
D.F. Travis and A. Travis, J. Ultrastruct. Res.39, 124 (1972).
A.L. Tappel, in: Pathobiology of cell membranes, vol. 1, p. 145. Eds B.F. Trump and A.U. Arstila, Academic Press, New York 1975.
B.E. Leibovitz and B.V. Siegel, J. Geront.35, 45 (1980).
H. David, Zentbl. allg. Path. path. Anat.124, 305 (1980).
A. Bass, E. Gutmann and V. Hanzlikova, Gerontologia21, 31 (1975).
R. Harris, in: The physiology and pathology of human aging, p. 109. Eds R. Coldman and M. Rockstein. Academic Press, New York 1975.
A. Salminen and V. Vihko, Pflügers Arch.389, 17 (1980).
J. Aune, Interdiscipl. Topics Geront.10, 44 (1976).
A. Salminen and V. Vihko, Acta physiol. scand.112, 89 (1981).
K. Wildenthal, R.S. Decker, A.R. Poole and J.T. Dingle, J. molec. cell. Cardiol.9, 859 (1977).
S. Schiaffino and V. Hanzlikova, J. Ultrastruct. Res.39, 1 (1972).
J.L.E. Ericsson, in: Lysosomes in biology and pathology, vol. 2, p. 345. Eds J.T. Dingle and H.B. Fell. North-Holland, Amsterdam 1973.
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This study was supported by the grants from the Ministry of Education and the Academy of Finland.
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Salminen, A., Kainulainen, H. & Vihko, V. Lysosomal changes related to ageing and physical exercise in mouse cardiac and skeletal muscles. Experientia 38, 781–782 (1982). https://doi.org/10.1007/BF01972267
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DOI: https://doi.org/10.1007/BF01972267