Summary
5-Hydroxytryptamine (5-HT) and hypoxanthine were isolated chromatographically from the holothurianPentacter crassa. This study was initiated as a result of the observed hypotensive activity of aP. crassa extract. This activity was also encountered in extracts of the holothuriansThelenota ananus andStichopus chloronatus and can be attributed to 5-HT.
Similar content being viewed by others
References
J.T. Baker and V. Murphy, Handbook of Marine Science-Compounds from Marine Organisms, vol. 1, 1976, and vol. 2, 1981. CRC Press, Ohio.
N.N. Osborne, Biochemistry of Characterised Neurones. Pergamon Press, New York 1978.
G. Mazzanti and D. Piccinelli, Comp. Biochem. Physiol.63C, 215 (1979).
G. Cimino and S. De Stefano, Comp. Biochem. Physiol.61C, 361 (1978).
N.N. Osborne, V. Neuhoff, E. Ewers and H.A. Robertson, Comp. Biochem. Physiol.63C, 209 (1979).
G.A. Cottrell and M.S. Laverack, A. Rev. Pharmac.8, 273 (1968).
V.W. Pentreath and J.L.S. Cobb, Biol. Rev.47, 363 (1972).
A.V. Juorio and H.A. Robertson, J. Neurochem.28, 573 (1977).
E. Ryberg, Acta zool., Stockh.55, 179 (1974).
H. Dolder, Histochemistry44, 313 (1975).
RRIMP Museum Specimen Numbers 1992, 1773, 1858. We thank Dr F. Rowe of the Australian Museum for the identification and K. Harada and R. Berthold for collection of the holothurians.
L.S. Goodman and A. Gilman, The Pharmacological Basis of Therapeutics, 3rd edn. Macmillan Co, New York, 1965.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gregson, R.P., Marwood, J.F. & Quinn, R.J. The occurrence of 5-hydroxytryptamine in the holothurian, Pentacter crassa. Experientia 37, 930–931 (1981). https://doi.org/10.1007/BF01971759
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01971759