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Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity

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Summary

Low voltage myocardial automaticity (LVA) was investigated by pharmacological modulations of the presynaptic and postsynaptic processes. The sensitivity of LVA both to inhibitor and stimulator of neutrotransmitter release suggests its involvement in LVA genesis. Moreover, LVA is blocked by the inhibition of the cyclic AMP system, supporting the participation of the c-AMP-dependent membrane phosphorylation in calcium-mediated cardiac electrogenesis.

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Authors and Affiliations

  1. Institute of Biological Physics, USSR Academy of Sciences, 142292, Pushchino, Moscow Region

    M. E. Saxon, V. G. Safronova, A. V. Lazarev, A. A. Freidin & Y. M. Kokoz

  2. Research Institute for Testing of the Chemical Compounds, Kupavna, Moscow Region, USSR

    M. E. Saxon, V. G. Safronova, A. V. Lazarev, A. A. Freidin & Y. M. Kokoz

Authors
  1. M. E. Saxon
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  2. V. G. Safronova
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  3. A. V. Lazarev
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  4. A. A. Freidin
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  5. Y. M. Kokoz
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Additional information

Acknowledgment. The generous gift of RM1 12330A from Prof. G. Guellen, Paris, and of tolbutamide from Prof. T. Hayakawa, Tokyo, are gratefully acknowledged.

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Saxon, M.E., Safronova, V.G., Lazarev, A.V. et al. Role of neurotransmitter release and cyclic AMP-dependent membrane phosphorylation in low voltage myocardial automaticity. Experientia 37, 731–734 (1981). https://doi.org/10.1007/BF01967949

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  • DOI: https://doi.org/10.1007/BF01967949

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