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In vitro activity of cefpodoxime against bacterial isolates obtained from patients with cancer

  • New Antimicrobial Agents
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Abstract

The in vitro activity of cefpodoxime, an oral cephalosporin ester, against 792 bacterial isolates representing 36 species was evaluated in comparison to that of ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Cefpodoxime inhibited the majority ofStreptococcus spp.,Haemophilus influenzae andProteus mirabilis at a concentration of ≤0.12 µg/ml. It was also active againstCitrobacter diversus, Escherichia coli, Klebsiella spp.,Proteus vulgaris, Serratia marcescens and methicillin-susceptibleStaphylococcus aureus isolates. Overall, cefpodoxime appeared to be less active than ciprofloxacin and TMP/SMX against many pathogens common in cancer patients.

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Authors and Affiliations

  1. Section of Infectious Diseases, Department of Medical Specialties, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

    K. V. I. Rolston, M. Messer, H. Nguyen, D. Ho, B. LeBlanc & G. P. Bodey

Authors
  1. K. V. I. Rolston
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  2. M. Messer
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  3. H. Nguyen
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  4. D. Ho
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  5. B. LeBlanc
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  6. G. P. Bodey
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Rolston, K.V.I., Messer, M., Nguyen, H. et al. In vitro activity of cefpodoxime against bacterial isolates obtained from patients with cancer. Eur. J. Clin. Microbiol. Infect. Dis. 10, 581–585 (1991). https://doi.org/10.1007/BF01967278

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  • DOI: https://doi.org/10.1007/BF01967278

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