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The effect of lodoxamide ethyl[diethyl N,N′-(2-chloro-5-cyano-m-phenylene)dioxamate] on in vivo anaphylactic reactions

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Abstract

Orally administered lodoxamide ethyl (U-42,718) inhibited anaphylactic reactions in a dose-related manner in the following test animals: (1) In the rat PCA reaction, excellent activity (75% inhibition at 0.1 mg/kg) was seen with a duration of activity of 30 min, (2) In the ascaris-sensitive primate (45% inhibition at 1.0 mg/kg) in lung parameters related to increased resistance and decreased compliance which persisted for up to 3 h, and (3) 50 mg/kg protected guinea pigs, sensitized to egg albumin, from lung function changes. Activity in these animal systems indicates that this orally active drug may hold promise in clinical asthma.

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Authors and Affiliations

  1. Hypersentivity Diseases Research, The Upjohn Company, 49001, Kalamazoo, Michigan, USA

    Herbert G. Johnson, Robert L. Griffin & John B. Wright

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  1. Herbert G. Johnson
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  2. Robert L. Griffin
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  3. John B. Wright
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Johnson, H.G., Griffin, R.L. & Wright, J.B. The effect of lodoxamide ethyl[diethyl N,N′-(2-chloro-5-cyano-m-phenylene)dioxamate] on in vivo anaphylactic reactions. Agents and Actions 9, 235–238 (1979). https://doi.org/10.1007/BF01966693

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  • DOI: https://doi.org/10.1007/BF01966693

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