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Cimetidine increases the pancreatic response to histamine

  • Allergy, Histamine and Kinins
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Abstract

The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2–0.8n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic (cimetidine 4 μmol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Veterinary Sc., University of Extremadura, 10071, Cáceres, Spain

    J. A. Pariente, L. P. Francis, G. M. Salido & J. A. Madrid

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  1. J. A. Pariente
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  2. L. P. Francis
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  3. G. M. Salido
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  4. J. A. Madrid
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Pariente, J.A., Francis, L.P., Salido, G.M. et al. Cimetidine increases the pancreatic response to histamine. Agents and Actions 30, 307–312 (1990). https://doi.org/10.1007/BF01966292

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