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Agents and Actions

, Volume 12, Issue 4, pp 425–430 | Cite as

The effects of cimetidine on histamine atrial chronotropic receptor activity

  • M. J. Hughes
Histamine and Kinins

Abstract

Clinically useful histamine antagonists have been reported to be specific for H1-or H2-receptors. However, data is accumulating that the specificity of those agents may be relative. This study was undertaken in an attempt to calrify this point.

Histamine stimulates the chronotropic responses of rabbit atria by acting on both H1- and H2-receptors. Cimetidine (H2-antagonist) and diphenhydramine (H1-antagonist) both cause some inhibition of the histamine response, but there is no evidence of competitive blockade with these antagonists given separately or in combination. 4-Methylhistamine (H2-agonist) stimulates chronotropic activity, and both H1-and H2-antagonists reduce this response to some degree. 2-Methylhistamine (H1-agonist) is a less effective agonist (perhaps rabbit atria contain fewer H1-receptors), but the response is also decreased by either H1-or H2-antagonists. These two ‘specific’ agonists were combined to stimulate the histamine responses, and the antagonists were given simultaneously. The results were qualitatively similar to those obtained with histamine. The question remains: (1) are these agonists and antagonists specific or (2) are the rabbit atrial chronotropic receptors not typical of the H1-and H2-type receptor?

Keywords

Histamine Cimetidine Receptor Activity Diphenhydramine Chronotropic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • M. J. Hughes
    • 1
  1. 1.Department of PhysiologyTexas Technical University Health Sciences CenterLubbockUSA

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