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Spontaneous reversal of ethinyl estradiol-induced cholestasis in the rat

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Summary

The spontaneous reversal of ethinyl estradiol-induced cholestasis has been documented 7 days after the last estrogen administration in the rat. This finding supports the hypothesis that estrogens produce only a transient functional failure of the hepatocytic structures responsible for bile secretion.

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References

  1. G.L. Plaa and B.G. Priestly, Pharmac. Rev.28, 207 (1977).

    Google Scholar 

  2. F. Kern, H. Eriksson, T. Curstedt and J. Sjovall, J. Lipid Res.18, 623 (1977).

    Article  CAS  PubMed  Google Scholar 

  3. T.A.J. Heikel and G.H. Lathe, Br. J. Pharmac.38, 593 (1970).

    Article  CAS  Google Scholar 

  4. P. Talalay, Meth. biochem. Analysis8, 119 (1960).

    CAS  Google Scholar 

  5. P. Roschlau, E. Berut and W. Gruber, Z. klin. Chem. klin. Biochem.12, 403 (1974).

    CAS  PubMed  Google Scholar 

  6. A. Svanborg and O. Vikrot, Acta med. scand.172, 615 (1965).

    Google Scholar 

  7. G.W. Snedecor and W.G. Cochran, in: Statistical Methods, p. 432. Iowa State University Press, Ames 1967.

    Google Scholar 

  8. J.J. Gumucio, L. Accatino, A.M. Macho and A. Contreras, Gastroenterology65, 651 (1973).

    Article  CAS  PubMed  Google Scholar 

  9. G. Stramentinoli, M. Gualano, P. Rovagnati and C. Di Padova, Biochem. Pharmac.28, 981 (1979).

    Article  CAS  Google Scholar 

  10. R.A. Davis and F. Kern, Gastroenterology72, 1045 (1977).

    Google Scholar 

  11. R.T. Holzbach, Am. J. Med.61, 367 (1976).

    Article  CAS  PubMed  Google Scholar 

  12. S. Erlinger, Lancet1, 533 (1978).

    Article  CAS  PubMed  Google Scholar 

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Author notes

  1. C. Di Padova & Paola Rovagnati

    Present address: 3rd Medical Clinic, University of Milan School of Medicine, Via Pace, 15, I-20122, Milan, Italy

Authors and Affiliations

  1. 1st Surgical Clinic, University of Milan School of Medicine, Via F. Sforza, 35, I-20122, Milan, Italy

    R. Tritapepe, C. Di Padova & Paola Rovagnati

Authors
  1. R. Tritapepe
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  2. C. Di Padova
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  3. Paola Rovagnati
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Additional information

Supported by Research grant CT-77, 0153304 from Consiglio Nazionale delle Ricerche, Rome, Italy.

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Tritapepe, R., Di Padova, C. & Rovagnati, P. Spontaneous reversal of ethinyl estradiol-induced cholestasis in the rat. Experientia 36, 580–581 (1980). https://doi.org/10.1007/BF01965813

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  • DOI: https://doi.org/10.1007/BF01965813

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