Abstract
Circumstantial evidence is presented that chloracetaldehyde is generated from cyclophosphamide by chemical oxidation in vitro with peroxide and might possibly be formed in vivo as a product of cyclophosphamide bioactivation.
Chloracetaldehyde has several attributes of an agent capable of suppressing cellular immunity. Thus it prevents a graft-versus-host reaction (both in vivo and in vitro), is cytostatic and under certain conditions can abrogate an ongoing immunopathy (EAE).
These properties are also exhibited by HN-2 and certain alkylating metabolites of cyclophosphamide.
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Whitehouse, M.W., Beck, F.J. & Kacena, A. Some (pharmacological) properties of chloracetaldehyde, an oxidation product and potential metabolite of cyclophosphamide. Agents and Actions 4, 34–43 (1974). https://doi.org/10.1007/BF01965490
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DOI: https://doi.org/10.1007/BF01965490