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Effect of spironolactone and phenobarbital on the plasma fibrinogen in rats

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Résumé

Par un dosage de 20 μM/100 g poids de spironolactone ou de phénobarbital pendant 3 jours, un niveau de fibrine élevé peut être produit chez des rats. En même temps, l'incorporation des aminoacides C14 au fibrinogène est aussi intense. Le phénobarbital est dans tous les cas plus efficace que le spironolactone. Dans notre cas, ces médicaments, connus comme inducteurs des enzymes microsomiques, augmentaient la synthèse protéique, enzymatiquement inactive du foie.

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Literatur

  1. M. I. Barnhardt andG. F. Anderson, Proc. Soc. exp. Biol. Med.110, 734 (1962).

    Article  Google Scholar 

  2. B. Solymoss, H. G. Classen andS. Varga, Proc. Soc. exp. Biol. Med.132, 940 (1969).

    Article  CAS  PubMed  Google Scholar 

  3. B. Solymoss, S. Tóth, S. Varga, J. Werringloer andG. Zsigmond, Can. J. Physiol. Pharmac.49, 841 (1971).

    Article  CAS  Google Scholar 

  4. H. Selye, J. pharm. Sci.60, 1 (1971).

    Article  CAS  PubMed  Google Scholar 

  5. K. Kovács, J. A. Blascheck andC. Gardell, Z. ges. exp. Med.152, 104 (1970).

    Article  Google Scholar 

  6. G. F. Grannis, Clin. Chem.16, 486 (1970).

    Article  CAS  PubMed  Google Scholar 

  7. A. C. Atencio andL. Lorand, Am. J. Physiol.219, 1161 (1970).

    Article  CAS  PubMed  Google Scholar 

  8. H. Remmer andJ. Casals, Naunyn-Schmiedebergs Arch. Pharmak.269, 455 (1971).

    Google Scholar 

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Authors and Affiliations

  1. Pathophysiological Institute of University Medical School, Debrecen 12, Hungary

    S. Tóth, T. Szilágyi & J. Csongor

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  1. S. Tóth
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  2. T. Szilágyi
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  3. J. Csongor
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Tóth, S., Szilágyi, T. & Csongor, J. Effect of spironolactone and phenobarbital on the plasma fibrinogen in rats. Experientia 28, 1289–1290 (1972). https://doi.org/10.1007/BF01965300

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