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Inhibition of Paf-acether-induced Edema of the Rat's Paw

  • Immunosuppression and Inflammation
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Abstract

Three classes of drugs were found, after their i.p. administration, to inhibit Paf-acether-induced edema of the rat's paw. These were beta-adrenergic agonists (isoproterenol, salbutamol), alpha-adrenergic antagonists (prazosin, ergotamine, yohimbine, phenoxybenzamine), and calcium entry blockers (nifedipine, verapamil, diltiazem). A number of other drugs including steroidal and nonsteroidal antiinflammatory agents, alpha-agonists, beta-antagonists, pyrilamine, atropine, methysergide, a lipoxygenase inhibitor, and a leukotriene antagonist did not inhibit the development of the edema. Propranolol, but not practolol, antagonized the inhibitory effect of isoproterenol which provided evidence for involvement of beta-2 receptors in the mechanism of action of the beta agonists. It is suggested that cellular calcium influx is involved in the edemagenic response observed after the injection of Paf-acether into the rat's paw.

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  1. 3M Center, Riker Laboratories, Inc, 55144, Saint Paul, Minnesota, U.S.A.

    K. F. Swingle & M. J. Reiter

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  1. K. F. Swingle
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  2. M. J. Reiter
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Swingle, K.F., Reiter, M.J. Inhibition of Paf-acether-induced Edema of the Rat's Paw. Agents and Actions 18, 359–365 (1986). https://doi.org/10.1007/BF01964997

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  • DOI: https://doi.org/10.1007/BF01964997

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