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Action of imidazole and some of its derivatives on nerve-muscle transmission in frog

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Abstract

Positive stimulatory action on nerve-muscle transmission for both imidazole and 2-methylimidazole has been shown. The effect of 2-methylimidazole was somewhat lesser in magnitude and slower in appearance than imidazole. 1-Methylimidazole had no effect; depressive action of histamine was demonstrated.

Both imidazole and 2-methylimidazole seem to act at the presynaptic region increasing acetylcholine release and act probably by interrelationship with calcium mechanisms. Possible role of imidazoles as the regulators of free calcium ions is suggested.

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Author notes

  1. R. S. Tuttle

    Present address: Masonic Medical Research Laboratory, Bleecker Street, 13501, Utica, New York, USA

Authors and Affiliations

  1. Department of Biogenic Amines, Molecular Research Center of the Polish Academy of Sciences, Narutowicza 60, 90-134, Łódź, Poland

    Z. Korsak (Olsen Memorial Fellow), R. S. Tuttle & Cz. Maśliński

Authors
  1. Z. Korsak
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  2. R. S. Tuttle
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  3. Cz. Maśliński
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Korsak, Z., Tuttle, R.S. & Maśliński, C. Action of imidazole and some of its derivatives on nerve-muscle transmission in frog. Agents and Actions 4, 404–409 (1974). https://doi.org/10.1007/BF01964943

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  • DOI: https://doi.org/10.1007/BF01964943

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