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Investigation of 1,3,4,9-tetrahydro-1-propylpyrano [3, 4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats1)

  • Immunosuppression and Inflammation
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Abstract

Prodolic acid (1,3,4,9-Tetrahydro-1-propylpyrano[3, 4-b] indole-1-acetic acid) showed anti-inflammatory, analgesic and antipyretic properties in several experimental models in rats. In chronic types of inflammation such as the adjuvant arthritis and the cotton pellet granuloma tests, prodolic acid was up to 17 times more potent than aspirin and approximately equipotent to phenylbutazone. In acute tests such as the carrageenin, the antipyretic and the analgesic tests the potency of prodolic acid was comparable to that of aspirin. The increased potency of prodolic acid in adjuvant arthritic rats may be taken as an indication that this new compound will be particularly effective in the treatment of rheumatoid arthritis and other arthritic conditions of man. The acute toxicity of prodolic acid was 3 times less than that of phenylbutazone. Prodolic acid produced very little gastrointestinal irritation in the highest tolerated doses, while aspirin and phenylbutazone were irritant. It is concluded that prodolic acid is a promising new anti-inflammatory agent particularly potent in chronic inflammation with low systemic and low gastrointestinal toxicity.

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Authors and Affiliations

  1. Department of Pharmacology, Ayerst Research Laboratories, P.O. Box 6115, H3C 3J1, Montreal, Quebec, Canada

    R. R. Martel, J. Klicius & F. Herr

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  1. R. R. Martel
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  2. J. Klicius
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  3. F. Herr
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Martel, R.R., Klicius, J. & Herr, F. Investigation of 1,3,4,9-tetrahydro-1-propylpyrano [3, 4-b] indole-1-acetic acid (prodolic acid), a new non-steroidal anti-inflammatory agent, in rats1). Agents and Actions 4, 370–376 (1974). https://doi.org/10.1007/BF01964939

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  • DOI: https://doi.org/10.1007/BF01964939

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