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Clinical programs for clinical research on AIDS: Description of a randomized prospective study of clindamycin versus pyrimethamine for prevention ofToxoplasma gondii infection

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Abstract

The risk of toxoplasmic encephalitis complicating AIDS appears largely limited to those HIV-infected patients with serologic evidence of pastToxoplasma gondii infection and low CD4 lymphocyte counts. The Community Programs for Clinical Research on AIDS has initiated a randomized, placebo-controlled trial to determine if clindamycin or pyrimethamine prophylactic regimens are effective and safe in preventing toxoplasmic encephalitis.

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Authors and Affiliations

  1. San Francisco Community Consortium on AIDS and San Francisco General Hospital, Ward 84, Bldg 80,995 Potrero, 94110, San Francisco, CA, USA

    M. A. Jacobson & C. Child

  2. Louisiana Community AIDS Research Program, Tulane University Medical Center, New Orleans, LA, USA

    C. L. Besch

  3. AIDS Division, The National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    R. Hafner

  4. Community Programs for Clinical Research on AIDS, The National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    K. Muth & L. Deyton

Authors
  1. M. A. Jacobson
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  2. C. L. Besch
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  3. C. Child
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  4. R. Hafner
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  5. K. Muth
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  6. L. Deyton
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Jacobson, M.A., Besch, C.L., Child, C. et al. Clinical programs for clinical research on AIDS: Description of a randomized prospective study of clindamycin versus pyrimethamine for prevention ofToxoplasma gondii infection. Eur. J. Clin. Microbiol. Infect. Dis. 10, 195–198 (1991). https://doi.org/10.1007/BF01964462

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  • DOI: https://doi.org/10.1007/BF01964462

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