Skip to main content
SpringerLink
Log in

Histamine release in dogs by Emulphor EL620

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

A vehicle containing ethanol and Emulphor EL620 lowers blood pressure and increases heart rate in morphinechloralose anesthetized dogs. These effects are associated with histamine release caused by Emulphor EL620.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J.L. Olsen, M. Makhani, K.H. Davis and M.E. Wall, J. Pharm. Pharmac.25, 344 (1973).

    Article  CAS  Google Scholar 

  2. J.C. Craddock, J.P. Davigon, C.L. Litterst and A.M. Guarino, J. Pharm. Pharmac.25, 345 (1973).

    Article  Google Scholar 

  3. M.D. Adams, J.T. Earnhardt, B.R. Martin, L.S. Harris, W.L. Dewey and R.K. Razdan, Experientia33, 1204 (1977).

    Article  CAS  PubMed  Google Scholar 

  4. M.D. Adams, J.T. Earnhardt, W.L. Dewey and L.S. Harris, J. Pharmac. exp. Ther.196, 649 (1976).

    CAS  Google Scholar 

  5. B.R. Martin, W.L. Dewey, L.S. Harris and J.S. Beckner, J. Pharmac. exp. Ther.196, 128 (1976).

    CAS  Google Scholar 

  6. B.R. Martin, W.L. Dewey, L.S. Harris and J.S. Beckner, Res. Commun. Chem. Path. Pharmac.17, 457 (1977).

    CAS  Google Scholar 

  7. R.D. Ford, R.L. Balster, W.L. Dewey and J.S. Beckner, Life Sci.20, 1993 (1977).

    Article  CAS  PubMed  Google Scholar 

  8. W. Lorenz, R. Meyer, A. Doenicke, A. Schmal, H.J. Reiman, M. Hutzel and E. Werle, Naunyn-Schmiedebergs Arch. Pharmak.269, 417 (1971).

    Google Scholar 

  9. M.A. Beaven, S. Jacobsen and Z. Horakova, Clin. chim. Acta37, 91 (1972).

    Article  CAS  PubMed  Google Scholar 

  10. S.H. Snider, R.J. Baldessarini and J. Axelrod, J. Pharmac. exp. Ther.153, 544 (1966).

    Google Scholar 

  11. W. Lorenz, Agents Actions5, 402 (1975).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pharmacology, Pfizer Central Research, Pfizer Inc., 06340, Groton, Connecticut, USA

    J. W. Constantine & W. S. Lebel

Authors
  1. J. W. Constantine
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. S. Lebel
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

We thank Dr Peter F. Moore for the histamine analyses, and Mr Wilfred K. McShane for help in preparation of the manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Constantine, J.W., Lebel, W.S. Histamine release in dogs by Emulphor EL620. Experientia 35, 338–339 (1979). https://doi.org/10.1007/BF01964338

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01964338

Keywords

Search

Navigation