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A possible preferential inhibition of chemotaxis of polymorphonuclear neutrophils by a chemical modification

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Summary

The modification of neutrophils with amino group blocking reagents of different chemical specificities showed that dansyl chloride caused inhibition of chemotaxis without suppression of random movement. Dansylated neutrophils, like control cells, ingested bacteria. Neither the stimulated cyanide-insensitive respiration, nor lactate production during phagocytosis, was affected significantly by dansylation as compared with the inhibition of directed movement.

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Authors and Affiliations

  1. Laboratory of Physiological Chemistry, School of Medicine, Juntendo University, Hongo, Bunkyo-ku, 113, Tokyo, Japan

    T. Yamashita, K. Takamori & Y. Tanaka

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  1. T. Yamashita
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  2. K. Takamori
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  3. Y. Tanaka
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Yamashita, T., Takamori, K. & Tanaka, Y. A possible preferential inhibition of chemotaxis of polymorphonuclear neutrophils by a chemical modification. Experientia 35, 1345–1347 (1979). https://doi.org/10.1007/BF01963999

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  • DOI: https://doi.org/10.1007/BF01963999

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