Skip to main content
SpringerLink
Log in

The effects of two neutral polymers on the geometry and deformability of the human erythrocyte

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Polyvinylpyrrolidone and dextran decrease cellular deformability. Changes in volume do not wholly account for the changes which imply a stiffening of the plasma membrane. The effects differ from those induced by charged macromolecules.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A.W.L. Jay, Biophys. J.15, 205 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. M.W. Rampling and J.A. Sirs, J. Physiol.223, 199 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. M.W. Rampling, Biochem. Pharmac.25, 751 (1976).

    Article  CAS  Google Scholar 

  4. K.M. Jan and S. Chien, J. gen. Physiol.61, 638 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. V.K. Hummel, Blut33, 322 (1969).

    CAS  Google Scholar 

  6. J.S.K. Fung and P.B. Canham, Biorheology11, 241 (1974).

    Article  CAS  PubMed  Google Scholar 

  7. V.K. Hummel, Blut9, 215 (1963).

    CAS  PubMed  Google Scholar 

  8. V.K. Hummel and L. v. Szczepanski, Blut9, 145 (1963).

    Article  CAS  PubMed  Google Scholar 

  9. D.E. Brooks, J. Colloid Interface Sci.43, 700 (1973).

    Article  CAS  Google Scholar 

  10. S. Chien, S. Shimchon, R.E. Abbott and K.M. Jan, J. Colloid Interface Sci.62, 461 (1977).

    Article  CAS  Google Scholar 

  11. L.S. Sewchand and P.B. Canham, Can. J. Physiol. Pharmac.54, 437 (1976).

    Article  CAS  Google Scholar 

  12. E. Ponder, Hemolysis and Related Phenomena. Grune and Stratton, New York 1948.

    Google Scholar 

  13. J.S. Beck, J. theor. Biol.75, 487 (1978).

    Article  CAS  PubMed  Google Scholar 

  14. N.S. Schachar, A.W.L. Jay, S. Rowlands, L. Skibo and F.H. Tyler, Can. J. Surg.17, 239 (1974).

    CAS  PubMed  Google Scholar 

  15. P. Teitel, Nature206, 409 (1965).

    Article  CAS  PubMed  Google Scholar 

  16. J.A. Sirs, Biorheology5, 1 (1968).

    Article  CAS  PubMed  Google Scholar 

  17. R.P. Rand and A.C. Burton, Biophys. J.4, 115 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. A.W.L. Jay and P.B. Canham, Biophys. J.17, 169 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. W. Birchmeier and S.J. Singer, J. Cell Biol.73, 647 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. M.P. Sheetz and S.J. Singer, J. Cell Biol.73, 638 (1977).

    Article  CAS  PubMed  Google Scholar 

  21. A. Elgsaeter, D.M. Shotton and D. Branton, Biochim. biophys. Acta426, 101 (1976).

    Article  CAS  PubMed  Google Scholar 

  22. G.L. Nicolson and R.G. Painter, J. Cell Biol.59, 395 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. V. Fowler and V. Bennett, J. supramolec. Struct.8, 215 (1978).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Calgary, T2N 1N4, Calgary, Alberta, Canada

    L. S. Sewchand, S. Leuchter, R. E. Lovlin, J. S. Beck & S. Rowlands

Authors
  1. L. S. Sewchand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Leuchter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. E. Lovlin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. S. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Rowlands
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

The work was supported by the Medical Research Council of Canada.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sewchand, L.S., Leuchter, S., Lovlin, R.E. et al. The effects of two neutral polymers on the geometry and deformability of the human erythrocyte. Experientia 35, 1320–1321 (1979). https://doi.org/10.1007/BF01963983

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01963983

Keywords

Search

Navigation