Abstract
The pharmacokinetics of lomefloxacin were studied after three days of oral administration of 400 mg/day lomefloxacin. Following the final dose the concentrations in serum, urine and cantharidin-induced inflammatory fluid were measured by a microbiological assay. The mean peak serum level was 4.9 mg/l at a mean time of 0.8 h. The mean serum elimination half-life was 6.2 h. The mean maximum inflammatory fluid level attained was 3.2 mg/l at 2.7 h. Urinary recovery accounted for the greater part of lome-floxacin's elimination.
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Hirose, T., Okezaki, E., Kato, H., Ito, Y., Inoue, M., Mitsuhashi, S.: In vitro and in vivo activity of NY-1987, a new difluorinated quinolone. Antimicrobial Agents and Chemotherapy 1987, 31: 854–859.
Wise, R., Andrews, J. M., Ashby, J. P.: The in vitro activity of lomefloxacin, a new quinolone antimicrobial, a comparison with other agents. Antimicrobial Agents and Chemotherapy 1988, 32: 617–622.
Stone, J. W., Andrews, J. M., Ashby, J. P., Griggs, D., Wise, R.: Pharmacokinetics and tissue penetration of orally administered lomefloxacin. Antimicrobial Agents and Chemotherapy 1988, 32: 1508–1510.
Wise, R., Gillett, A. P., Cadge, B., Durham, S. R., Baker, S.: The influence of protein binding upon tissue fluid levels of six β-lactam antibiotics. Journal of Infectious Diseases 1980, 142: 77–82.
Bennett, J. V., Brodie, J. L., Benner, E. J., Kirby, W. M. M.: Simplified accurate method for antibiotic assay of clinical specimens. Applied Microbiology 1966, 14: 170–177.
Adhami, Z. N., Wise, R., Weston, D., Crump, B.: The pharmacokinetics and tissue penetration of norfloxacin. Journal of Antimicrobial Chemotherapy 1984, 13: 87–92.
Griggs, D. J., Wise, R., Kirkpatrick, B., Ashby, J. P.: Pharmacokinetics and tissue penetration of fleroxacin, a new trifluoroquinolone. Antimicrobial Agents and Chemotherapy 1987, 31: 161–163.
Wise, R., Lister, D., McNulty, C. A. M., Griggs, D., Andrews, J. M.: The comparative pharmacokinetics of five quinolones. Journal of Antimicrobial Chemotherapy 1986, 18, Supplement D: 71–81.
Crump, B., Wise, R., Dent, J.: The pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrobial Agents and Chemotherapy 1983, 24: 784–786.
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Kavi, J., Stone, J., Andrews, J.M. et al. Tissue penetration and pharmacokinetics of lomefloxacin following multiple doses. Eur. J. Clin. Microbiol. Infect. Dis. 8, 168–170 (1989). https://doi.org/10.1007/BF01963906
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DOI: https://doi.org/10.1007/BF01963906