Abstract
Methods of analysis of the anticancer drug hexamethylmelamine, its physicochemical properties, its therapeutic uses and its fatein vivo upon oral administration, are described. The data are taken in part from the literature, in part from our own studies.
The low solubility of hexamethylmelamine in water has prevented the parenteral administration of the drug to humans. The preparation of the water-soluble monohydrochloride of hexamethylmelamine, which may be suitable for this purpose, is reported, as well as its physicochemical characteristics and methods of analysis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ames, M.M., G. Powis, J.S. Kovach andR.T. Eagan (1979)Cancer Res. 39, 5016–5021.
Bellamy, L.J. (1975)The Infra-red Spectra of Complex Molecules, 3rd ed. Chapman & Hall, London, 17, 316.
Bryan, G.T., andA.L. Gorske (1968)J. Chromatog. 34, 67–71.
Chang, S.C., A.B. Demilo, C.W. Woods andA.B. Borkovec (1968)J. Econ. Entomol. 61, 1357–1365.
Cincotta, J.J., andR. Feinland (1962)Anal. Chem. 34, 774–776.
Cumber, A.J., andW.C.J. Ross (1977)Chem.-Biol. Interactions 17, 349–357.
Feigl, F., andV. Anger (1975)Spot tests in organic analysis, translated by R.E.Oesper. English Ed. VII. Elsevier Scientific Publ. Comp., Amsterdam-Oxford-New York, 251–252.
Gescher, A., M. D'Incalci, R. Fanelli andP. Farina (1980)Life Sci. 26, 147–154.
Hulshoff, A., J.P. Neijt, C.F.A. Smulders, A.C. Van Loenen andH.M. Pinedo (1980a)J. Chromatog. 181, 363–371.
Hulshoff, A., J.P. Neijt, C.F.A. Smulders andA.C. Van Loenen (1980b)Proc. Am. Assoc. Cancer Res. 21, 301.
D'incalci, M., G. Bolis, C. Mangioni, L. Morasca andS. Garattini (1978)Cancer Treat. Rep. 62, 2117–2119.
D'incalci, M., P. Morazzoni andC. Pantarotto (1979)Anal. Biochem. 99, 441–449.
D'incalci, M., P. Farina, C. Sessa, E. Erba, R. Madonna andC. Mangioni (1980)Therap. Drug Monitoring 2, 187–188.
Johnson, B.L., R.I. Fisher, R.A. Bender, V.T. De Vita, B.A. Chabner andR.C. Young (1978)Cancer 42, 2157–2161.
Kaiser, D.W., J.T. Thurston, J.R. Dudley, F.C. Schaefer, I. Hechenbleikner andD. Holm-Hansen (1951)J. Am. Chem. Soc. 73, 2984–2986.
Kreilgard, B., T. Higuchi andA.J. Repta (1975)J. Pharm. Sci. 64, 1850–1855.
Legha, S.S., M. Slavik andS.K. Carter (1976)Cancer 38, 27–35.
Morimoto, M., D. Green, A. Rahman, A. Goldin andP.S. Schein (1980)Cancer Res. 40, 2762–2767.
Neijt, J.P., A.C.M. Van Lindert, C.P.J. Vendrik, K.J. Roozendaal, A. Struyvenberg andH.M. Pinedo (1979)Neth. J. Med. 22, 38–44.
Pohloudek-Fabini, R., andTh. Beyrich (1975)Organische Analyse. Akademische Verlagsgesellschaft Geest & Porting K-G, Leipzig, 338.
Rutty, C.J., andT.A. Connors (1977)Biochem. Pharmacol. 26, 2385–2391.
Wehrli, F.W., and T.Wirthlin (1976)Interpretation of Carbon-13 NMR Spectra. Heyden, London-New York-Rheine.
Williams, D.H., andI. Fleming (1966)Spectroscopic Methods in Organic Chemistry. McGraw-Hill, London, 126.
Worzalla, J.F., B.M. Johnson, G. Ramirez andG.T. Bryan (1973)Cancer Res. 33, 2810–2815.
Young, R.C., B.A. Chabner, S.P. Hubbard, R.I. Fisher, R.A. Bender, T. Anderson, R.M. Simon, G.P. Canellos andV.T. De Vita (1978)New Engl. J. Med. 299, 1261–1266.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Van De Vaart-Van Zutphen, H.P.C., Smulders, C.F.A., Renema, J. et al. Hexamethylmelamine and hexamethylmelamine hydrochloride. Pharmaceutisch Weekblad Scientific Edition 4, 25–31 (1982). https://doi.org/10.1007/BF01963657
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01963657