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Baluchistine, a new bisbenzylisoquinoline alkaloid

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Summary

The new phenolic bisbenzylisoquinoline alkaloid (+)-baluchistine, found inBerberis baluchistanica Ahrendt (Berberidaceae), has been assigned structure1. O-Methylation using ethereal diazomethane yields (+)-obaberine (2). Baluchistine is the 1 alkaloid of the oxyacanthine-berbamine group to incroporate a free phenolic function at C-6.

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References

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  2. M. Shamma, in: The Isoquinoline Alkaloids, p. 149. Academic Press, New York 1972.

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Authors and Affiliations

  1. Department of Pharmacy, Gomal University, Dera Ismail Khan, N.W.F.P., Pakistan

    G. A. Miana, J. E. Foy, R. D. Minard & M. Shamma

  2. Department of Chemistry, Pennsylvania State University, 16802, University Park, Pennsylvania, USA

    G. A. Miana, J. E. Foy, R. D. Minard & M. Shamma

Authors
  1. G. A. Miana
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  2. J. E. Foy
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  3. R. D. Minard
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  4. M. Shamma
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Additional information

this project was supported by NIH research grant CA-11450, awarded by the National Cancer Institute, PHS/DHEW.

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Miana, G.A., Foy, J.E., Minard, R.D. et al. Baluchistine, a new bisbenzylisoquinoline alkaloid. Experientia 35, 1137–1138 (1979). https://doi.org/10.1007/BF01963244

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  • DOI: https://doi.org/10.1007/BF01963244

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