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Endogenous inhibitor of ecdysone synthesis in crabs

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Summary

Attempts to isolate the molt-inhibiting hormone (MIH) of crustaceans from crab eyestalks (ES) resulted in the characterization of xanthurenic acid as an inhibitor of ecdysone biosynthesis in the cultured Y-organ-complex (YOC) homogenate. It was also found that 3-hydroxyl-l-kynurenine present in the ES is transformed into xanthurenic acid in the YOC and body fluid. Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450.

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Authors and Affiliations

  1. Suntory Institute for Bioorganic Research, Shimamoto-cho, Mishima-gun, 618, Osaka, Japan

    Y. Naya, K. Kishida, M. Sugiyama, M. Murata, W. Miki, M. Ohnishi & K. Nakanishi

Authors
  1. Y. Naya
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  2. K. Kishida
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  3. M. Sugiyama
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  4. M. Murata
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  5. W. Miki
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  6. M. Ohnishi
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  7. K. Nakanishi
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Additional information

Acknowledgments. We thank Prof. M. Oka (Nagasaki University) and Dr J. Cappuzo (Oceanographic Inst.) for information on Y-organ and molting stages, Dr J. Termini and Mr J. Cesarelli (Columbia University) for organ excision of blue crabs and experiments in the early stage of this study, the Japan Sea Farming Association for aqua culture of crabs, Prof. Y. Umebachi (Kanazawa University) for a gift of 3-OH-l-Kyn, and Mr J. Rudloe (Gulf Specimen Co.) for collection and shipping of some selected crabs. This study was partially supported by NIH grant AI 10 187 (to K. N., at Columbia University).

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Naya, Y., Kishida, K., Sugiyama, M. et al. Endogenous inhibitor of ecdysone synthesis in crabs. Experientia 44, 50–52 (1988). https://doi.org/10.1007/BF01960242

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  • DOI: https://doi.org/10.1007/BF01960242

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