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The antifertility action of α-chlorohydrin: metabolism by rat and boar sperm

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Summary

The male antifertility agent α-chlorohydrin (I) is metabolized by rat and boar sperm to β-chloroactaldehyde (III), β-chlorolactate (IV) and Cl− and not to the proposed active metabolite, α-chlorohydrin-1-phosphate (III). It is proposed that β-chlorolactaldehyde is produced intracellularly by a specific enzyme and that this is the metabolite responsible for the species-specific antifertility activity of α-chlorohydrin.

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References

  1. A.R. Jones, Life Sci.23, 1625 (1978).

    Article  CAS  Google Scholar 

  2. P.M. Mashford and A.R. Jones, Experientia34, 1267 (1978).

    Article  CAS  Google Scholar 

  3. The pure enzyme was obtained commercially, isolated fromCandida mycoderma.

  4. D.E. Brooks, J. Reprod. Fert.56, 593 (1979).

    Article  CAS  Google Scholar 

  5. P.D.C. Brown-Woodman, H. Mohri, T. Mohri, D.A.I. Suter and I.G. White, Biochem. J.170, 23 (1978).

    Article  CAS  Google Scholar 

  6. A.G. Dawson, Biochim. biophys. Acta499, 85 (1977).

    Article  CAS  Google Scholar 

  7. A.R. Jones, Xenobiotica5, 155 (1975).

    Article  CAS  Google Scholar 

  8. A.R. Jones, D.H. Milton and C. Murcott, Xenobiotica8, 573 (1978).

    Article  CAS  Google Scholar 

  9. A.I. Vogel, in: Practical Organic Chemistry, 3rd edn. p. 1067. Longmans, London 1957.

    Google Scholar 

  10. A.G. Dawson, Biochem. J.130, 525 (1972).

    Article  CAS  Google Scholar 

  11. C. Walsh, in: Enzymatic Reaction Mechanisms, pp. 322, 593. Freeman, San Francisco 1979.

    Google Scholar 

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Author notes

  1. A. G. Dawson

    Present address: Department of Biochemistry, School of Life Sciences, N.S.W. Institute of Technology, 2065, Gore Hill, N.S.W., Australia

Authors and Affiliations

  1. Department of Biochemistry, University of Sydney, 2006, Sydney, N.S.W., Australia

    A. R. Jones, Denise Stevenson, Primrose Hutton & A. G. Dawson

Authors
  1. A. R. Jones
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  2. Denise Stevenson
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  3. Primrose Hutton
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  4. A. G. Dawson
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Additional information

This work was supported by The National Health and Medical Research Council of Australia.

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Jones, A.R., Stevenson, D., Hutton, P. et al. The antifertility action of α-chlorohydrin: metabolism by rat and boar sperm. Experientia 37, 340–341 (1981). https://doi.org/10.1007/BF01959850

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  • DOI: https://doi.org/10.1007/BF01959850

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