Abstract
Arterial thrombo-embolism is an unusual complication in inflammatory bowel disease in adults and children. Cerebral arterial disease has been reported on only a few occasions. There are only two previous case reports of arterial disease occurring in a child with Crohn disease. However in both instances the arterial disease was part of a generalised Takayasu arteritis which resulted in multi-organ involvement. This report describes a 14-year-old boy who developed seizures before a histological diagnosis ofCrohn disease was made. These seizures were the result of a vascular lesion which was confined to the right middle cerebral artery.
Conclusion
Crohn disease as well as ulcerative colitis should be considered as a possible cause of cerebrovascular accidents in children
Similar content being viewed by others
Abbreviations
- IBD :
-
inflammatory bowel disease
References
Bargen JA, Barker NW (1936) Extensive arterial and venous thrombosis complicating chronic ulcerative colitis. Arch Intern Med 58:17–31
Booth IW (1991) Chronic inflammatory bowel disease. Arch Dis Child 66742–744
Braverman D, Bogoch A (1978) Arterial thrombosis in ulcerative colitis. Am J Dig Dis 23:1148–1150
Burbidge FJ, Huang S, Bayless TM (1975) Clinical manifestations of Crohn's disease in children and adolescence. Pediatrics 55:866
Calkins BM, Lilienfeld Am, Garland CF, Mendeloff AI (1984) Trends in incidence rates of ulcerative colitis and Crohns disease. Dig Dis Sci 29:913
Crohn BB (1967) Granulomatous disease of the large and small bowel, a histological survey. Gastroenterology 52:767
Crohn BB, Ginzburg L, Oppenheimer GD (1932) Regional Enteritis: A pathological and clinical entity. JAMA 99:1323
Kehoe EL, Newcomer KL (1964) Thromboembolic phenomena in ulcerative colitis. Arch Intern Med 113:711–715
Koenigs KP, McPhedran P, Spiro HM (1987) Thrombosis in inflammatory bowel disease. J Clin Gastroenterol 9:627–631
Lake AM, Stauffer JQ, Stuart MJ (1978) Hemostatic alterations in inflammatory bowel disease. Dig Dis Sci 23:897–902
Lama A, Borda IT, Inwood MJ, et al (1975) Coagulation studies in ulcerative colitis and Crohn's Disease. Gastroenterology 68:245–251
Lloyd-Still Jd, Tomasi L (1989) Neurovascular and thromboembolic complications of inflammatory bowel disease in childhood. J Pediatric Gastroenterol Nutr 9:461–466
Markowitz RL, Ment LR, Gryboski JD (1989) Cerebral thromboembolic disease in pediatric and adult inflammatory disease: case report and review of the literature. J Pediatric Gastroenterol Nutr 8:413–420
Miller RC, Jackson M, Larson E (1971) Regional enteritis in early infancy. Am J Dis Child 122:301–311
Paradis K, Bernstein ML, Adelson JW (1985) Thrombosis as a complication of inflammatory bowel disease in children: a report of 4 cases. J Pediatr Gastroenterol Nutr 4:659–662
Rankin GB, Watts HD, Melynk CS, et al (1979) The National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 77:914–920
Schneiderman JH, Sharpe JA, Sutton DMC (1979) Cerebral and retinal vascular complications of inflammatory bowel disease. Ann Neurol 5:331–337
Talbot RW, Heppell J, Dazois RR, Beart RW (1986) Vascular complications of inflammatory bowel disease. Mayo Clin Proc 61:140–145
Teja K, Crum CP, Friedman C (1980) Giant cell arteritis in Crohn's disease. An unreported association. Gastroenterology 78:796–802
Van Elburg RM, Henar EL, Bijleverd MA, Pins TR, Heymans HSA (1992) Vascular compromise prior to intestinal manifestations of Crohn's disease in a 14 year old girl. J Pediatric Gastroenterol Nutr 14:97–100
Wilske KR, Healey LA (1967) Polymyalgia rheumatica. A manifestation of systemic giant cell arteritis. Ann Intern Med 66:77
Yassinger S, Adelman R, Cantor D, Bolt RJ (1976) Association of inflammatory bowel disease and large vascular lesions. Gastroenterology 71:844–846
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gormally, S.M., Bourke, W., Kierse, B. et al. Isolated cerebral thrombo-embolism and Crohn disease. Eur J Pediatr 154, 815–818 (1995). https://doi.org/10.1007/BF01959788
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01959788